Effects of Plasma Treatment with Purified Protein A and Staphylococcus aureus Cowan I on Spontaneous Animal Neoplasms

Jeffrey S. Klausner; Timothy D. O'Brien; Wesley J. Miller; Richard F. Brande

Effects of Plasma Treatment with Purified Protein A and Staphylococcus aureus Cowan I on Spontaneous Animal Neoplasms

Jeffrey S. Klausner, Timothy D. O'Brien, Wesley J. Miller, Richard F. Brande

Research output: Contribution to journal › Article › peer-review

Abstract

Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose columns, and a semiautomatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was noted in only one of 11 dogs. In contrast, infusion of small volumes of plasma after incubation with heat and formalin-treated Staphylococcus aureus Cowan I resulted in a tumoricidal response in five of six animals. These results suggest that tumor necrosis is probably not induced by Protein A-mediated removal of humoral “blocking” factors.

Original language	English (US)
Pages (from-to)	1263-1269
Number of pages	7
Journal	Cancer Research
Volume	45
Issue number	3
State	Published - Mar 1 1985

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abstract = "Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose columns, and a semiautomatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was noted in only one of 11 dogs. In contrast, infusion of small volumes of plasma after incubation with heat and formalin-treated Staphylococcus aureus Cowan I resulted in a tumoricidal response in five of six animals. These results suggest that tumor necrosis is probably not induced by Protein A-mediated removal of humoral “blocking” factors.",

author = "Klausner, {Jeffrey S.} and O'Brien, {Timothy D.} and Miller, {Wesley J.} and Brande, {Richard F.}",

year = "1985",

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language = "English (US)",

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AU - Klausner, Jeffrey S.

AU - O'Brien, Timothy D.

AU - Miller, Wesley J.

AU - Brande, Richard F.

PY - 1985/3/1

Y1 - 1985/3/1

N2 - Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose columns, and a semiautomatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was noted in only one of 11 dogs. In contrast, infusion of small volumes of plasma after incubation with heat and formalin-treated Staphylococcus aureus Cowan I resulted in a tumoricidal response in five of six animals. These results suggest that tumor necrosis is probably not induced by Protein A-mediated removal of humoral “blocking” factors.

AB - Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose columns, and a semiautomatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was noted in only one of 11 dogs. In contrast, infusion of small volumes of plasma after incubation with heat and formalin-treated Staphylococcus aureus Cowan I resulted in a tumoricidal response in five of six animals. These results suggest that tumor necrosis is probably not induced by Protein A-mediated removal of humoral “blocking” factors.

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JO - Cancer Research

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ER -

Effects of Plasma Treatment with Purified Protein A and Staphylococcus aureus Cowan I on Spontaneous Animal Neoplasms

Abstract

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