Effects of Plasma Treatment with Purified Protein A and Staphylococcus aureus Cowan I on Spontaneous Animal Neoplasms

Jeffrey S. Klausner, Timothy D. O'Brien, Wesley J. Miller, Richard F. Brande

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose columns, and a semiautomatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was noted in only one of 11 dogs. In contrast, infusion of small volumes of plasma after incubation with heat and formalin-treated Staphylococcus aureus Cowan I resulted in a tumoricidal response in five of six animals. These results suggest that tumor necrosis is probably not induced by Protein A-mediated removal of humoral “blocking” factors.

Original languageEnglish (US)
Pages (from-to)1263-1269
Number of pages7
JournalCancer Research
Volume45
Issue number3
StatePublished - Mar 1 1985

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