The goal of this pilot study was to determine the effects of phenytoin on cocaine self-administration in a human laboratory model. Subjects were randomized to either phenytoin (n=6) or placebo (n=7). Those assigned to phenytoin treatment received a single oral loading dose of 20 mg/kg. The phenytoin and placebo treatment groups did not differ in the number of tokens, valued at $5, exchanged for cocaine. Similarly, the cardiovascular and subjective response to cocaine administration did not show a statistically significant treatment effect. In this laboratory model, phenytoin did not alter either the self-administration or effects of cocaine. Copyright (C) 1999 Elsevier Science Ireland Ltd.
Bibliographical noteFunding Information:
This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400). We would like to thank to David Babb, Susan Dudish-Poulsen, Micah Hammer and Daniella Jentzch for technical assistance, Dr Nina Graves for helpful discussion and the General Clinical Research Center nursing staff.
- Oral loading