Effects of phenobarbital and 3-methylcholanthrene induction on the formation of three glucuronide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, NNK

Keyphrases

• 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 100%
• Phenobarbital 100%
• 3-methylcholanthrene 100%
• Glucuronide Metabolites 100%
• Gluc 60%
• Hydroxylation 50%
• N-oxidation 30%
• Human Hepatocytes 20%
• Hemoglobin Adducts 20%
• Tobacco 10%
• Oncogenesis 10%
• Active Metabolite 10%
• Hepatocytes 10%
• Metabolism 10%
• DNA Adducts 10%
• Methyl 10%
• Carcinogen 10%
• Pyridyl 10%
• Glucuronide 10%
• Methylene 10%
• Direct Conjugation 10%
• Carcinogenic Potential 10%
• Causative Agents 10%
• Adduct Formation 10%
• Rat Hepatocytes 10%
• Glucuronide Conjugate 10%
• DNA Adduct Formation 10%
• Nitro Group 10%
• UDP-glucuronosyltransferase 10%
• Glucuronidation 10%
• Human Lung Cancer 10%
• N-nitroso 10%
• N-glucuronidation 10%
• Aglycon 10%
• Microsomal Metabolism 10%
• Butanone 10%

Pharmacology, Toxicology and Pharmaceutical Science

• NNK 100%
• Glucuronide 100%
• Methylcholanthrene 100%
• 4 (Methylnitrosamino) 1 (3 Pyridyl) 1 Butanone 100%
• Phenobarbital 100%
• Rat 31%
• Hemoglobins 12%
• High Performance Liquid Chromatography 6%
• Carcinogen 6%
• Aglycone 6%
• Lung Cancer 6%
• Active Metabolite 6%
• 2 Butanone 6%
• Carcinogenesis 6%
• Glucuronosyltransferase 6%
• Uridine Diphosphate 6%
• Carbene 6%