Effects of phencyclidine on shock-induced aggression in rats

James Cleary, Juan Herakovic, Alan Poling

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The effects of phencyclidine were assessed under two distinctive paradigms. In a traditional laboratory assay where pairs of rats received intermittent foot shocks, phencyclidine at doses of 0.5 to 2.0 mg/kg decreased the number of shock-elicited fighting bouts in dose-dependent fashion. Similar dose-dependent decreases in biting were also observed under a procedure where single restrained rats received intermittent tail shocks, which evoked biting of an inanimate target.

Original languageEnglish (US)
Pages (from-to)813-818
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume15
Issue number5
DOIs
StatePublished - Nov 1981

Keywords

  • Biting
  • Phencyclidine
  • Rats
  • Shock-induced aggression

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