Effects of phencyclidine on shock-induced aggression in rats

James Cleary; Juan Herakovic; Alan Poling

doi:10.1016/0091-3057(81)90027-7

Effects of phencyclidine on shock-induced aggression in rats

James Cleary, Juan Herakovic, Alan Poling

Neurology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effects of phencyclidine were assessed under two distinctive paradigms. In a traditional laboratory assay where pairs of rats received intermittent foot shocks, phencyclidine at doses of 0.5 to 2.0 mg/kg decreased the number of shock-elicited fighting bouts in dose-dependent fashion. Similar dose-dependent decreases in biting were also observed under a procedure where single restrained rats received intermittent tail shocks, which evoked biting of an inanimate target.

Original language	English (US)
Pages (from-to)	813-818
Number of pages	6
Journal	Pharmacology, Biochemistry and Behavior
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(81)90027-7
State	Published - Nov 1981

Keywords

Biting
Phencyclidine
Rats
Shock-induced aggression

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10.1016/0091-3057(81)90027-7

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title = "Effects of phencyclidine on shock-induced aggression in rats",

abstract = "The effects of phencyclidine were assessed under two distinctive paradigms. In a traditional laboratory assay where pairs of rats received intermittent foot shocks, phencyclidine at doses of 0.5 to 2.0 mg/kg decreased the number of shock-elicited fighting bouts in dose-dependent fashion. Similar dose-dependent decreases in biting were also observed under a procedure where single restrained rats received intermittent tail shocks, which evoked biting of an inanimate target.",

keywords = "Biting, Phencyclidine, Rats, Shock-induced aggression",

author = "James Cleary and Juan Herakovic and Alan Poling",

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AU - Herakovic, Juan

AU - Poling, Alan

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N2 - The effects of phencyclidine were assessed under two distinctive paradigms. In a traditional laboratory assay where pairs of rats received intermittent foot shocks, phencyclidine at doses of 0.5 to 2.0 mg/kg decreased the number of shock-elicited fighting bouts in dose-dependent fashion. Similar dose-dependent decreases in biting were also observed under a procedure where single restrained rats received intermittent tail shocks, which evoked biting of an inanimate target.

AB - The effects of phencyclidine were assessed under two distinctive paradigms. In a traditional laboratory assay where pairs of rats received intermittent foot shocks, phencyclidine at doses of 0.5 to 2.0 mg/kg decreased the number of shock-elicited fighting bouts in dose-dependent fashion. Similar dose-dependent decreases in biting were also observed under a procedure where single restrained rats received intermittent tail shocks, which evoked biting of an inanimate target.

KW - Biting

KW - Phencyclidine

KW - Rats

KW - Shock-induced aggression

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JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

IS - 5

ER -

Effects of phencyclidine on shock-induced aggression in rats

Abstract

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