Effects of pharmacological manipulations of NMDA-receptors on deliberation in the Multiple-T task

Anna Blumenthal, Adam Steiner, Kelsey Seeland, A. David Redish

    Research output: Contribution to journalArticlepeer-review

    20 Scopus citations

    Abstract

    Both humans and non-human animals have the ability to navigate and make decisions within complex environments. This ability is largely dependent upon learning and memory processes, many of which are known to depend on NMDA-sensitive receptors. When humans come to difficult decisions they often pause to deliberate over their choices. Similarly, rats pause at difficult choice points. This behavior, known as vicarious trial and error (VTE), is hippocampally dependent and entails neurophysiological representations of expectations of future outcomes in hippocampus and downstream structures. In order to determine the dependence of VTE behaviors on NMDA-sensitive receptors, we tested rats on a Multiple-T choice task with a reward-delivery reversal known to elicit VTE. Rats under the influence of NMDA-receptor antagonists (CPP) showed a significant reduction in VTE, particularly at the reward reversal, implying a role for NMDA-sensitive receptors in the generation of vicarious trial and error behaviors.

    Original languageEnglish (US)
    Pages (from-to)376-384
    Number of pages9
    JournalNeurobiology of Learning and Memory
    Volume95
    Issue number3
    DOIs
    StatePublished - Mar 2011

    Keywords

    • CPP
    • CPP: 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid
    • DCS
    • DCS: D-cycloserine
    • Decision-making
    • NMDA-receptor
    • VTE
    • VTE: vicarious trial and error
    • Vicarious trial and error

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