Effects of persistent Fontan fenestration patency on cardiopulmonary exercise testing variables

M. Elisabeth Heal; Lanier B. Jackson; Andrew M. Atz; Ryan J. Butts

doi:10.1111/chd.12451

Effects of persistent Fontan fenestration patency on cardiopulmonary exercise testing variables

M. Elisabeth Heal, Lanier B. Jackson, Andrew M. Atz, Ryan J. Butts

Pediatric Cardiology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Cardiopulmonary exercise testing (CPET) aids in clinical assessment of patients with Fontan circulation. Effects of persistent fenestration on CPET variables have not been clearly defined. Associations between fenestration and CPET variables at anaerobic threshold (AT) and peak exercise were explored in the Pediatric Heart Network Fontan Cross-Sectional Study cohort. Fenestration patency was associated with a greater decrease in oxygen saturation from rest to peak exercise (fenestration −4.9 ± 3.8 v. nonfenestration −3 ± 3.5; P <.001). Physiological dead space at peak exercise was higher in fenestrated v. nonfenestrated (25.2 ± 16.1 v. 21.4 ± 15.2; P =.03). There was a weak association between fenestration patency and maximal work and heart rate. Fenestration patency was also weakly correlated with oxygen pulse, work and VE/VCO2 at AT. The effect of persistent fenestration on CPET measurements was minimal in this study, likely due to the cross-sectional design.

Original language	English (US)
Pages (from-to)	399-402
Number of pages	4
Journal	Congenital Heart Disease
Volume	12
Issue number	4
DOIs	https://doi.org/10.1111/chd.12451
State	Published - Jul 1 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

Keywords

Exercise testing
Fontan
fenestration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1111/chd.12451

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794490

Find It

Find It at U of M Libraries

Cite this

@article{7a7218aa805442c5b20b8b929e6a38fb,

title = "Effects of persistent Fontan fenestration patency on cardiopulmonary exercise testing variables",

abstract = "Cardiopulmonary exercise testing (CPET) aids in clinical assessment of patients with Fontan circulation. Effects of persistent fenestration on CPET variables have not been clearly defined. Associations between fenestration and CPET variables at anaerobic threshold (AT) and peak exercise were explored in the Pediatric Heart Network Fontan Cross-Sectional Study cohort. Fenestration patency was associated with a greater decrease in oxygen saturation from rest to peak exercise (fenestration −4.9 ± 3.8 v. nonfenestration −3 ± 3.5; P <.001). Physiological dead space at peak exercise was higher in fenestrated v. nonfenestrated (25.2 ± 16.1 v. 21.4 ± 15.2; P =.03). There was a weak association between fenestration patency and maximal work and heart rate. Fenestration patency was also weakly correlated with oxygen pulse, work and VE/VCO2 at AT. The effect of persistent fenestration on CPET measurements was minimal in this study, likely due to the cross-sectional design.",

keywords = "Exercise testing, Fontan, fenestration",

author = "Heal, {M. Elisabeth} and Jackson, {Lanier B.} and Atz, {Andrew M.} and Butts, {Ryan J.}",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2017",

month = jul,

day = "1",

doi = "10.1111/chd.12451",

language = "English (US)",

volume = "12",

pages = "399--402",

journal = "Congenital Heart Disease",

issn = "1747-079X",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Effects of persistent Fontan fenestration patency on cardiopulmonary exercise testing variables

AU - Heal, M. Elisabeth

AU - Jackson, Lanier B.

AU - Atz, Andrew M.

AU - Butts, Ryan J.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Cardiopulmonary exercise testing (CPET) aids in clinical assessment of patients with Fontan circulation. Effects of persistent fenestration on CPET variables have not been clearly defined. Associations between fenestration and CPET variables at anaerobic threshold (AT) and peak exercise were explored in the Pediatric Heart Network Fontan Cross-Sectional Study cohort. Fenestration patency was associated with a greater decrease in oxygen saturation from rest to peak exercise (fenestration −4.9 ± 3.8 v. nonfenestration −3 ± 3.5; P <.001). Physiological dead space at peak exercise was higher in fenestrated v. nonfenestrated (25.2 ± 16.1 v. 21.4 ± 15.2; P =.03). There was a weak association between fenestration patency and maximal work and heart rate. Fenestration patency was also weakly correlated with oxygen pulse, work and VE/VCO2 at AT. The effect of persistent fenestration on CPET measurements was minimal in this study, likely due to the cross-sectional design.

AB - Cardiopulmonary exercise testing (CPET) aids in clinical assessment of patients with Fontan circulation. Effects of persistent fenestration on CPET variables have not been clearly defined. Associations between fenestration and CPET variables at anaerobic threshold (AT) and peak exercise were explored in the Pediatric Heart Network Fontan Cross-Sectional Study cohort. Fenestration patency was associated with a greater decrease in oxygen saturation from rest to peak exercise (fenestration −4.9 ± 3.8 v. nonfenestration −3 ± 3.5; P <.001). Physiological dead space at peak exercise was higher in fenestrated v. nonfenestrated (25.2 ± 16.1 v. 21.4 ± 15.2; P =.03). There was a weak association between fenestration patency and maximal work and heart rate. Fenestration patency was also weakly correlated with oxygen pulse, work and VE/VCO2 at AT. The effect of persistent fenestration on CPET measurements was minimal in this study, likely due to the cross-sectional design.

KW - Exercise testing

KW - Fontan

KW - fenestration

UR - http://www.scopus.com/inward/record.url?scp=85020737143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020737143&partnerID=8YFLogxK

U2 - 10.1111/chd.12451

DO - 10.1111/chd.12451

M3 - Article

C2 - 28618202

AN - SCOPUS:85020737143

SN - 1747-079X

VL - 12

SP - 399

EP - 402

JO - Congenital Heart Disease

JF - Congenital Heart Disease

IS - 4

ER -

Effects of persistent Fontan fenestration patency on cardiopulmonary exercise testing variables

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this