Effects of pentobarbital and d-amphetamine on oral phencyclidine self-administration in rhesus monkeys

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Abstract

Three rhesus monkeys self-administered phencyclidine (0.25 mg/ml) during daily 3-hr sessions. Water was also available under a concurrent fixed-ratio (FR) 16 schedule. In Experiment 1, saline or three doses of pentobarbital (2.5, 5 or 10 mg/kg) were injected 10 min before phencyclidine (and water) self-administration sessions. The 2.5 mg/kg pentobarbital dose increased phencyclidine-maintained responding, the 5 mg/kg dose produced mixed effects among the three monkeys, and the 10 mg/kg dose consistently decreased phenycyclidine-maintained responding. Subsequently, a saccharin solution (0.03% wt/vol) replaced phencyclidine, and the pentobarbital pretreatment procedure was repeated. Pentobarbital produced dose-related decreases in saccharin-maintained responding. In Experiment 2, saline or three doses of d-amphetamine (0.05, 0.1 or 0.2 mg/kg) were injected 10 min before the phencyclidine self-administration sessions. The 0.05 mg/kg dose produced increases in phencyclidine-maintained responding, while the two higher doses produced dose dependent decreases in responding. When a saccharin solution (0.03%, wt/vol) replaced phencyclidine during the daily sessions, d-amphetamine produced only dose-related decreases in saccharin-maintained responding. These results indicate that pentobarbital and d-amphetamine have a biphasic effect on phencyclidine-maintained behavior; low doses increased responding and high doses decreased responding.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume20
Issue number1
DOIs
StatePublished - Jan 1984

Bibliographical note

Funding Information:
ACKNOWLEDGEMENTS The author wishes to thank Dana Stotz, Heidi Noetzel, James Pedersen and Kevin Ryan for their assistance in conducting the experiments. This work was supported by NIDA grant DA 02486 and a grant from the Committee on Problems of Drug Dependence. Inc. to M. E. Carroll and NIDA grant DA 00944 to R. A. Meisch.

Keywords

  • Drug interaction
  • Oral drug self-administration
  • Pentobarbital
  • Phencyclidine
  • Rhesus monkeys
  • Saccharin
  • d-Amphetamine

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