Effects of pentazocine and tripelennamine on analgesia

James Cleary; Scott Wallace; Deborah Grossett; Mitchell Picker; Alan Poling

doi:10.1016/0091-3057(83)90389-1

Effects of pentazocine and tripelennamine on analgesia

James Cleary, Scott Wallace, Deborah Grossett, Mitchell Picker, Alan Poling

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

The analgesic effects of pentazocine and tripelennamine, alone and in combination, were assessed in rats with a hot plate apparatus. In Experiment 1, the combination of tripelennamine with chronic pentazocine produced analgesia at doses which were not analgesic when the drugs were given alone. This combination also reestablished analgesia in subjects made tolerant to pentazocine's effects. In Experiment 2, development of tolerance to the analgesic effects of pentazocine was delayed by addition of tripelennamine. These data may contribute to a rationale for the current popularity of combined pentazocine and tripelennamine abuse.

Original language	English (US)
Pages (from-to)	911-915
Number of pages	5
Journal	Pharmacology, Biochemistry and Behavior
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/0091-3057(83)90389-1
State	Published - Dec 1983

Bibliographical note

Funding Information:
1The reported studies were supported by a Faculty Research Grant and Fellowship awarded to Alan Poling by Western Michigan University.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Analgesia
Drug Interaction
Pentazocine
Rats
Tripelennamine

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10.1016/0091-3057(83)90389-1

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AU - Wallace, Scott

AU - Grossett, Deborah

AU - Picker, Mitchell

AU - Poling, Alan

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Effects of pentazocine and tripelennamine on analgesia

Abstract

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Keywords

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