Effects of pentazocine and tripelennamine on analgesia

James Cleary, Scott Wallace, Deborah Grossett, Mitchell Picker, Alan Poling

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The analgesic effects of pentazocine and tripelennamine, alone and in combination, were assessed in rats with a hot plate apparatus. In Experiment 1, the combination of tripelennamine with chronic pentazocine produced analgesia at doses which were not analgesic when the drugs were given alone. This combination also reestablished analgesia in subjects made tolerant to pentazocine's effects. In Experiment 2, development of tolerance to the analgesic effects of pentazocine was delayed by addition of tripelennamine. These data may contribute to a rationale for the current popularity of combined pentazocine and tripelennamine abuse.

Original languageEnglish (US)
Pages (from-to)911-915
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume19
Issue number6
DOIs
StatePublished - Dec 1983

Bibliographical note

Funding Information:
1The reported studies were supported by a Faculty Research Grant and Fellowship awarded to Alan Poling by Western Michigan University.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Analgesia
  • Drug Interaction
  • Pentazocine
  • Rats
  • Tripelennamine

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