Effects of neonatal treatment with clomipramine on adult ethanol related behavior in the rat

L. A. Hilakivi, J. D. Sinclair, I. T. Hilakivi

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Male rat pups were deprived of active (REM) sleep by giving daily injections of clomipramine between 8 and 21 days after birth. At the age of 55 days their ambulation and defecation in the open-field were tested. Thereafter, beginning at the age of 66 days, the voluntary ethanol consumption of the rats was tested for 4 weeks. Compared to saline-treated rats, the CLM rats consumed more ethanol, tended to be more active in the open-field, and responded with a decrase in ambulation to an ethanol dose which stimulated locomotion in controls rats. These results indicate that neonatal treatment with clomipramine has an influence on later ethanol-related behavior in rats.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalDevelopmental Brain Research
Volume15
Issue number1
DOIs
StatePublished - 1984
Externally publishedYes

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