Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals

Christopher Ring; Christopher R. France; Mustafa al'Absi; Louisa Edwards; David McIntyre; Douglas Carroll; Una Martin

doi:10.1016/j.biopsycho.2007.10.006

Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals

Christopher Ring, Christopher R. France, Mustafa al'Absi, Louisa Edwards, David McIntyre, Douglas Carroll, Una Martin

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.

Original language	English (US)
Pages (from-to)	191-196
Number of pages	6
Journal	Biological Psychology
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/j.biopsycho.2007.10.006
State	Published - Feb 2008

Bibliographical note

Funding Information:
This work was supported by NIH grant R01 HL64794.

Keywords

Endogenous opioids
Hypertension
Hypoalgesia
Naltrexone
Pain

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10.1016/j.biopsycho.2007.10.006

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title = "Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals",

abstract = "An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.",

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AU - France, Christopher R.

AU - al'Absi, Mustafa

AU - Edwards, Louisa

AU - McIntyre, David

AU - Carroll, Douglas

AU - Martin, Una

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AB - An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.

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Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals

Abstract

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Keywords

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