Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals

Christopher Ring, Christopher R. France, Mustafa N al'Absi, Louisa Edwards, David McIntyre, Douglas Carroll, Una Martin

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalBiological Psychology
Volume77
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Endogenous opioids
  • Hypertension
  • Hypoalgesia
  • Naltrexone
  • Pain

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