Effects of mobility and cognition on maintenance of independence and survival among women in late life

Study of Osteoporotic Fractures (SOF)

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: We examined the effects of mobility and cognition on maintenance of independence among women in late life. Methods: Prospective 5-year study of 1,010 independent community-dwelling women (mean age 88.0 years) participating in the Study of Osteoporotic Fractures Year 20 examination (2006-2008). Mobility, ascertained by walk speed, was categorized as good (≥0.9 m/s), intermediate (>0.6 m/s to <0.9 m/s), or poor (≤0.6 m/s). Cognitive status, adjudicated based on neuropsychological tests, was classified as normal or impaired (mild cognitive impairment or dementia). Loss of independence was defined as being unable to perform ≥2 activities of daily living or nursing home residence at 5-year follow-up. Possible outcomes were alive and independent, alive and dependent, and deceased. Results: Four hundred and twenty-three (41.9%) participants were independent at follow-up, whereas 208 (20.6%) were alive but dependent; 379 (37.5%) had died. Compared to women with good mobility, those with slow walk speed were less likely to be independent (risk ratio, [RR] 0.40, 95% confidence interval [CI] 0.29-0.52), after controlling for cognition and other risk factors. Similarly, those with impaired cognition were less likely to be independent, after controlling for walk speed and other risk factors (RR 0.60, 95% CI 0.49-0.71). Women with slow walk speed and impaired cognition were 6-fold less likely to be independent at follow-up compared to those with good walk speed and normal cognition (RR 0.15, 95% CI 0.08-0.23). Conclusions: Both mobility and cognition are associated with maintenance of independence among the oldest old of women even after accounting for each other and other conventional predictors.

Original languageEnglish (US)
Pages (from-to)1251-1257
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume73
Issue number9
DOIs
StatePublished - Jan 1 2018

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Cognition
Maintenance
Survival
Dementia
Odds Ratio
Confidence Intervals
Independent Living
Osteoporotic Fractures
Neuropsychological Tests
Activities of Daily Living
Nursing Homes
Cognitive Dysfunction

Keywords

  • Cognition
  • Disablement process
  • Independent living
  • Physical performance
  • Successful aging

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

Cite this

Effects of mobility and cognition on maintenance of independence and survival among women in late life. / Study of Osteoporotic Fractures (SOF).

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 73, No. 9, 01.01.2018, p. 1251-1257.

Research output: Contribution to journalArticle

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abstract = "Background: We examined the effects of mobility and cognition on maintenance of independence among women in late life. Methods: Prospective 5-year study of 1,010 independent community-dwelling women (mean age 88.0 years) participating in the Study of Osteoporotic Fractures Year 20 examination (2006-2008). Mobility, ascertained by walk speed, was categorized as good (≥0.9 m/s), intermediate (>0.6 m/s to <0.9 m/s), or poor (≤0.6 m/s). Cognitive status, adjudicated based on neuropsychological tests, was classified as normal or impaired (mild cognitive impairment or dementia). Loss of independence was defined as being unable to perform ≥2 activities of daily living or nursing home residence at 5-year follow-up. Possible outcomes were alive and independent, alive and dependent, and deceased. Results: Four hundred and twenty-three (41.9{\%}) participants were independent at follow-up, whereas 208 (20.6{\%}) were alive but dependent; 379 (37.5{\%}) had died. Compared to women with good mobility, those with slow walk speed were less likely to be independent (risk ratio, [RR] 0.40, 95{\%} confidence interval [CI] 0.29-0.52), after controlling for cognition and other risk factors. Similarly, those with impaired cognition were less likely to be independent, after controlling for walk speed and other risk factors (RR 0.60, 95{\%} CI 0.49-0.71). Women with slow walk speed and impaired cognition were 6-fold less likely to be independent at follow-up compared to those with good walk speed and normal cognition (RR 0.15, 95{\%} CI 0.08-0.23). Conclusions: Both mobility and cognition are associated with maintenance of independence among the oldest old of women even after accounting for each other and other conventional predictors.",
keywords = "Cognition, Disablement process, Independent living, Physical performance, Successful aging",
author = "{Study of Osteoporotic Fractures (SOF)} and Diem, {Susan J.} and Lui, {Li Yung} and Lisa Langsetmo and Brent Taylor and Cawthon, {Peggy M.} and Cauley, {Jane A.} and Ensrud, {Kristine E.}",
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T1 - Effects of mobility and cognition on maintenance of independence and survival among women in late life

AU - Study of Osteoporotic Fractures (SOF)

AU - Diem, Susan J.

AU - Lui, Li Yung

AU - Langsetmo, Lisa

AU - Taylor, Brent

AU - Cawthon, Peggy M.

AU - Cauley, Jane A.

AU - Ensrud, Kristine E.

PY - 2018/1/1

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N2 - Background: We examined the effects of mobility and cognition on maintenance of independence among women in late life. Methods: Prospective 5-year study of 1,010 independent community-dwelling women (mean age 88.0 years) participating in the Study of Osteoporotic Fractures Year 20 examination (2006-2008). Mobility, ascertained by walk speed, was categorized as good (≥0.9 m/s), intermediate (>0.6 m/s to <0.9 m/s), or poor (≤0.6 m/s). Cognitive status, adjudicated based on neuropsychological tests, was classified as normal or impaired (mild cognitive impairment or dementia). Loss of independence was defined as being unable to perform ≥2 activities of daily living or nursing home residence at 5-year follow-up. Possible outcomes were alive and independent, alive and dependent, and deceased. Results: Four hundred and twenty-three (41.9%) participants were independent at follow-up, whereas 208 (20.6%) were alive but dependent; 379 (37.5%) had died. Compared to women with good mobility, those with slow walk speed were less likely to be independent (risk ratio, [RR] 0.40, 95% confidence interval [CI] 0.29-0.52), after controlling for cognition and other risk factors. Similarly, those with impaired cognition were less likely to be independent, after controlling for walk speed and other risk factors (RR 0.60, 95% CI 0.49-0.71). Women with slow walk speed and impaired cognition were 6-fold less likely to be independent at follow-up compared to those with good walk speed and normal cognition (RR 0.15, 95% CI 0.08-0.23). Conclusions: Both mobility and cognition are associated with maintenance of independence among the oldest old of women even after accounting for each other and other conventional predictors.

AB - Background: We examined the effects of mobility and cognition on maintenance of independence among women in late life. Methods: Prospective 5-year study of 1,010 independent community-dwelling women (mean age 88.0 years) participating in the Study of Osteoporotic Fractures Year 20 examination (2006-2008). Mobility, ascertained by walk speed, was categorized as good (≥0.9 m/s), intermediate (>0.6 m/s to <0.9 m/s), or poor (≤0.6 m/s). Cognitive status, adjudicated based on neuropsychological tests, was classified as normal or impaired (mild cognitive impairment or dementia). Loss of independence was defined as being unable to perform ≥2 activities of daily living or nursing home residence at 5-year follow-up. Possible outcomes were alive and independent, alive and dependent, and deceased. Results: Four hundred and twenty-three (41.9%) participants were independent at follow-up, whereas 208 (20.6%) were alive but dependent; 379 (37.5%) had died. Compared to women with good mobility, those with slow walk speed were less likely to be independent (risk ratio, [RR] 0.40, 95% confidence interval [CI] 0.29-0.52), after controlling for cognition and other risk factors. Similarly, those with impaired cognition were less likely to be independent, after controlling for walk speed and other risk factors (RR 0.60, 95% CI 0.49-0.71). Women with slow walk speed and impaired cognition were 6-fold less likely to be independent at follow-up compared to those with good walk speed and normal cognition (RR 0.15, 95% CI 0.08-0.23). Conclusions: Both mobility and cognition are associated with maintenance of independence among the oldest old of women even after accounting for each other and other conventional predictors.

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KW - Disablement process

KW - Independent living

KW - Physical performance

KW - Successful aging

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