Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

Keli L. Hippen, Michael Loschi, Jemma Nicholls, Kelli P.A. MacDonald, Bruce R. Blazar

Research output: Contribution to journalShort survey

10 Scopus citations

Abstract

Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.

Original languageEnglish (US)
Article number57
JournalFrontiers in immunology
Volume9
Issue numberJAN
DOIs
StatePublished - Jan 31 2018

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Keywords

  • Graft-versus-host disease
  • ITreg
  • MicroRNA
  • Regulatory T cell
  • TTreg

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