@inproceedings{a437ad0794e24b409a8ef0210dff68c8,
title = "EFFECTS OF METHYL AND FLUORINE SUBSTITUTION ON THE METABOLIC ACTIVATION AND TUMORIGENICITY OF POLYCYCLIC AROMATIC HYDROCARBONS.",
abstract = "The effects of methyl and fluorine substitution on the metabolic activation and tumorigenicity of polycyclic aromatic hydrocarbons (PAH) are reviewed. The structural requirements favoring tumorigenicity of methylated PAH are a bay region methyl group and a free peri position, both adjacent to an unsubstituted angular ring. The enhancing effect of a bay region methyl group on PAH tumorigenicity appears to be due to the relatively high reactivity with DNA and exceptional tumorigenicity of a dihydrodiol epoxide metabolite having a methyl group and epoxide ring in the same bay region.",
author = "Hecht, {Stephen S.} and Shantu Amin and Melikian, {Assieh A.} and LaVoie, {Edmond J.} and Dietrich Hoffmann",
year = "1985",
language = "English (US)",
isbn = "0841209243",
series = "ACS Symposium Series",
publisher = "ACS",
pages = "85--105",
editor = "Harvey, {Ronald G.}",
booktitle = "ACS Symposium Series",
}