Effects of low amine diet on gastric endocrine cell proliferation in the rat

Michael W. Mulholland, John P. Delaney

Research output: Contribution to journalArticlepeer-review


The effects of a liquid diet low in amines on gastrin cell and somatostatin cell functions were studied in the rat. Significant decreases in portal gastrin levels (44% at 5 days) were noted in animals maintained on a liquid diet (Vivonex). Refeeding solid rat chow resulted in a significant, but transient, hypergastrinemia. Portal somatostatin levels were significantly increased during ingestion of the liquid diet. With refeeding, portal somatostatin promptly returned to baseline values. Gastrin cell density decreased progressively during liquid diet ingestion (37% decline by Day 5). Antral somatostatin cell numbers were increased during this time period (86% versus controls). With solid chow refeeding, both gastrin cell and somatostatin cell densities returned to baseline.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalJournal of Surgical Research
Issue number2
StatePublished - Aug 1988
Externally publishedYes

Bibliographical note

Funding Information:
’ This work was supported, in part, by NIH Grant DK37393-01.


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