Effects of lovastatin on breast cancer cells: A proteo-metabonomic study

Keyphrases

• Breast Cancer Cells 100%
• Lovastatin 100%
• Metabonomics 100%
• Downstream Targets 30%
• Lactones 20%
• AKT Pathway 20%
• Lovastatin Acid 20%
• Protein Expression 10%
• Retinoblastoma 10%
• E2F Transcription Factor 1 (E2F1) 10%
• Proteomics 10%
• Breast Cancer 10%
• Tumor 10%
• Cell Proliferation 10%
• Antitumor Activity 10%
• Cofilin 10%
• Statins 10%
• Gene Regulation 10%
• Phosphatase 10%
• Cell Survival 10%
• Metabolic Profiling 10%
• Cdc42 10%
• Cholesterol-lowering Drugs 10%
• AKT1 10%
• Metabolic Consequences 10%
• Pleiotropic Effects 10%
• Breast Cancer Cell Lines 10%
• RhoA 10%
• Decreased Expression 10%
• Profiling Techniques 10%
• Lipid Biosynthesis 10%
• Non-interactive 10%
• GTPase 10%
• Glycolytic 10%
• Proteomic Profiling 10%
• Krebs Cycle 10%
• DJ-1 10%
• Ras Homolog Gene Family Member A 10%
• Survival Response 10%
• Membrane-bound Form 10%
• Tensin Homolog 10%
• Active Membranes 10%
• Progressors 10%
• Prohibitin 10%
• Isoprenylation 10%
• Proliferation Response 10%
• Active Ras 10%
• G3BP1 10%
• NDRG1 10%
• Minichromosome Maintenance Protein 7 10%
• Rho Inhibitor 10%
• MutS Homolog 2 10%

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 100%
• Lovastatin 100%
• Signal Transduction 16%
• Proteomics 16%
• Phosphatase 8%
• Lipogenesis 8%
• Citric Acid Cycle 8%
• CDC42 8%
• E2F1 8%
• E2F 8%
• Protein Expression 8%
• Multigene Family 8%
• Cell Survival 8%
• Upregulation 8%
• down Regulation 8%
• Cell Proliferation 8%
• Antineoplastic Activity 8%
• Minichromosome Maintenance 8%
• Krebs Cycle 8%
• Isoprenylation 8%
• GTPase 8%
• Statin 8%
• Cofilin 8%
• Retinoblastoma 8%
• Tensin 8%
• Prohibitin 8%
• NDRG1 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Breast Cancer 100%
• Mevinolin 100%
• Lactone 16%
• Antitumor Activity 8%
• Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 8%
• Phosphatase 8%
• DNA Mismatch Repair Protein MSH2 8%
• Guanosine Triphosphatase 8%
• Tensin 8%
• Hypocholesterolemic Agent 8%
• Prohibitin 8%
• Cofilin 8%
• Neoplasm 8%
• Retinoblastoma 8%
• Minichromosome Maintenance Protein 7 8%