Effects of laparoscopic Roux-en-Y gastric bypass on bone mineral density and markers of bone turnover

Kosisochi M. Obinwanne, Kevin P. Riess, Kara J. Kallies, Michelle A. Mathiason, Brian R. Manske

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background Despite multiple beneficial effects of weight loss after laparoscopic Roux-en-Y gastric bypass (LRYGB), the influence on bone mineral density (BMD) remains largely unknown. Our objective was to evaluate the changes in BMD and serum/urine bone markers after LRYGB.

Methods Thirty-four women undergoing LRYGB were prospectively enrolled and underwent bone densitometry and serum/urine analysis preoperatively and 1 year postoperative. Changes ≥.025 g/cm2 in hip, femoral neck, and spine BMD and decreases>2% in total BMD were considered significant. Statistical analysis included paired t tests and McNemar's test.

Results Mean age was 44.6 years. Body mass index at the preoperative and 1-year postoperative intervals were 46.7 and 29.6 kg/m2, respectively. Mean hip, femoral neck, and spine (L1-L4) BMD was 1.191 versus 1.087 g/cm2 (P<.001), 1.105 versus 1.032 g/cm2 (P<.001), and 1.323 versus 1.277 g/cm2 (P<.001) at the preoperative and 1 year postoperative intervals, respectively. Mean total BMD decreased from 1.328 preoperatively to 1.251 g/cm2 at 1 year postoperative (P<.001). The decreases in BMD were 5.8%, 6.5%, 3.5%, and 8.8% for hip, femoral neck, spine (L1-L4) and total BMD from preoperative to 1 year postoperative. The proportion of patients with low vitamin D levels decreased from 55% preoperatively to 21% at 1 year postoperative (P =.004). Elevated osteocalcin and bone alkaline phosphatase was observed in 4% and 63% (P<.001), and 14% and 41% (P =.011) of patients preoperatively and at 1 year postoperative, respectively.

Conclusion BMD and bone markers changed significantly after LRYGB. Current recommendations for supplementation in post-LRYGB women may need to be reevaluated.

Original languageEnglish (US)
Pages (from-to)1056-1062
Number of pages7
JournalSurgery for Obesity and Related Diseases
Issue number6
StatePublished - Nov 1 2014


  • Bone density
  • Bone resorption
  • Calcium
  • Gastric bypass
  • Osteocalcin
  • Vitamin D

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