Effects of labetalol treatment on the physiological and subjective response to smoked cocaine

Mehmet Sofuoglu, Scott Brown, David A. Babb, Paul R. Pentel, Dorothy K. Hatsukami

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Adrenergic receptors mediate some of the physiological and possibly behavioral effects of cocaine. The purpose of this study was to investigate the effect of treatment with a peripherally acting adrenergic blocking drug labetalol on the cardiovascular and subjective response to repeated deliveries of smoked cocaine. In this double-blind, placebo-controlled, crossover study, 12 cocaine users were treated with a single 100 or 200 mg dose of labetalol, or placebo in each of three experimental sessions. Starting 2 h after the medication treatment, subjects received three doses of 0.4 mg/kg smoked cocaine, 30 min apart. Labetalol treatment significantly attenuated the cocaine-induced increases in heart rate and systolic blood pressure. This effect of labetalol on the cardiovascular response did not decrease with repeated cocaine deliveries. The subjective response to smoked cocaine deliveries was not affected by labetalol treatment. These results suggest that labetalol effectively attenueates the systolic blood pressure and heart rate increases induced by repeated doses of smoked cocaine, but does not alter subjective effects. (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalPharmacology Biochemistry and Behavior
Issue number2
StatePublished - Feb 2000

Bibliographical note

Funding Information:
This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400). We would like to thank GCRC nursing staff for their technical assistance.

Copyright 2007 Elsevier B.V., All rights reserved.


  • Adrenergic receptors
  • Cocaine
  • Crack cocaine
  • Labetalol

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