Effects of intravenous triacylglycerol emulsions on hepatic metabolism and blood metabolites in fasted dairy cows

D. G. Mashek, S. J. Bertics, R. R. Grummer

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The objective was to determine the effects of intravenous infusion of triacylglycerol (TAG) emulsions derived from different lipid sources on energy metabolism during a 4-d fast. Six nonpregnant, nonlactating multiparous Holstein cows were randomly assigned to treatments in a replicated 3 x 3 Latin Square design. Treatments included intravenous infusion of tallow, linseed oil, or fish oil emulsions at a rate of 0.54 g of TAG/kg of body weight per day; infusions were concurrent with a 4-d fast. The emulsions were administered for 20 to 30 min every 4 h throughout the 4-d fast. Cows were fed ad libitum for 24 d between the fast/infusion periods. Infusion of tallow, linseed oil, or fish oil emulsions increased plasma concentrations of palmitic acid, linolenic acid, and eicosapentaenoic and docosahexaenoic acids, respectively. Infusion of linseed oil emulsion decreased plasma TAG concentrations compared with tallow and fish oil treatments, which were similar. Infusion of the tallow emulsion resulted in the highest concentrations of plasma nonesterified fatty acid (NEFA), insulin, and glucose, whereas the infusion derived from linseed oil had the lowest NEFA and β-hydroxybutyric acid concentrations. The different TAG emulsions had no effect on total or peroxisomal oxidation of [1-14C]oleic acid in liver homogenates. Liver TAG content increased 12.0, 7.8, and 14.1 μg/μg of DNA during the fast for tallow, linseed oil, and fish oil treatments, respectively; linseed oil was different from fish oil and tended to be different from tallow.

Original languageEnglish (US)
Pages (from-to)100-109
Number of pages10
JournalJournal of Dairy Science
Volume88
Issue number1
DOIs
StatePublished - Jan 2005

Bibliographical note

Funding Information:
We recognize Bioproducts, Inc., Pioneer Hi-Bred International Inc ., Degussa Corp., ADM Alliance Nutrition Inc., Kemin Americas, Church and Dwight Co., Inc., Land O’Lakes Inc., Diamond V Mills., and Zinpro Corp., for partial financial support of this work.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Bovine
  • Energy metabolism
  • Fatty liver

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