Effects of interrupting prolonged sitting on postprandial glycemia and insulin responses: A network meta-analysis

Minghui Quan, Pengcheng Xun, Hua Wu, Jing Wang, Wei Cheng, Meng Cao, Tang Zhou, Tao Huang, Zan Gao, Peijie Chen

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose: To evaluate the effectiveness of physical activity (PA) interrupting prolonged sitting (PS) on postprandial glycemia and insulin responses among adults. Methods: PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, PsycINFO, and the China National Knowledge Infrastructure databases were searched through September 30, 2020. Randomized controlled trials (RCTs) that examined the effect of all forms of PA interrupting PS on postprandial glycemia and/or insulin responses among adults without chronic diseases were included in this study. The risk of bias of included studies was evaluated based on the Cochrane tool. A network meta-analysis was performed to estimate the summary standardized mean differences (SMDs) with 95% confidence intervals (95%CIs) with random effects. Results: Thirty crossover RCTs were included in our review. These RCTs included 9 types of interventions that interrupted PS. When compared to PS by itself, light-intensity PA intermittent interrupting (LPA-INT) PS and moderate-intensity PA intermittent interrupting (MPA-INT) PS significantly lowered postprandial glycemia (SMD = –0.46, 95%CI: –0.70 to –0.21; SMD = –0.69, 95%CI: –1.00 to –0.37, respectively) and significantly reduced postprandial insulin response (SMD = –0.46, 95%CI: –0.66 to –0.26; SMD = –0.47, 95%CI: –0.77 to –0.17, respectively). Results of the clustered ranking plot indicated that MPA-INT was the most effective intervention in lowering postprandial glycemia and insulin responses. Conclusion: Replacing PS with MPA-INT or LPA-INT has a positive effect in reducing postprandial glycemia and insulin responses, with MPA-INT being the optimal intervention strategy.

Original languageEnglish (US)
JournalJournal of Sport and Health Science
DOIs
StateAccepted/In press - 2021

Bibliographical note

Funding Information:
The authors thank Dr Shi Qu, from the Institute of Urology, West China Hospital of Sichuan University, for his advice on data analysis. This work was supported by grants to MQ from the National Key Research and Development Program of China (2020YFC2003301, 2020YFC2007005), National Natural Science Foundation of China (81703252) and Shanghai Committee of Science and Technology of China (19080503000), and to HW from the Public Welfare Technology Project of the Zhejiang Science Department (LGF18H170006).

Funding Information:
The authors thank Dr Shi Qu, from the Institute of Urology, West China Hospital of Sichuan University, for his advice on data analysis. This work was supported by grants to MQ from the National Key Research and Development Program of China (2020YFC2003301, 2020YFC2007005), National Natural Science Foundation of China (81703252) and Shanghai Committee of Science and Technology of China (19080503000), and to HW from the Public Welfare Technology Project of the Zhejiang Science Department (LGF18H170006). MQ performed the literature search, conceived and designed the study, analyzed the data, and drafted the manuscript; PX analyzed the data, advised on interpretation of the data, and critically revised the manuscript; HW and JW performed the literature search; MC and TZ performed the literature search and assessed the risk of bias of included studies; WC, TH, and ZG critically revised the manuscript; PC advised on the analysis and interpretation of the data and critically revised the manuscript. All authors have read and approved the final version of the manuscript, and agree with the order of presentation of the authors. The authors declare that they have no competing interests.

Publisher Copyright:
© 2021

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

  • Glucose
  • Insulin
  • Meta-analytic review
  • Physical activity interruption
  • Prolonged sitting

PubMed: MeSH publication types

  • Journal Article
  • Review

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