Effects of inhalational general anaesthetics on intact Daphnia magna (Cladocera: Crustacea)

J. Douglas McKenzre, Peter Calow, Walter S. Nimmo

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1. The potency of general anaesthetics was studied in the water flea, Daphnia magna. 2. Anaesthesia was defined as a reversible lack of movement to stimulation with strong light. 3. ec50s for methoxyflurane, halothane, isoflurane and enflurane were 0.095, 1.005, 1.170 and 1.422 (% v v in 100% oxygen). 4. Nitrous oxide had no significant additive effect on the ec50s of the other agents, nor any effect on its own. 5. Oxygen concentrations in the carrier gas did not significantly affect the ec50 of halothane. 6. Clonal differences in halothane potency were observed.

Original languageEnglish (US)
Pages (from-to)9-13
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Issue number1
StatePublished - Jan 1992
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgements-This work was supportedb y grants from the SheffieldU niversityR esearchF und and the Drug Absorption Foundation of Edinburgh.W e would like to thankM r Mark Cosgrovea nd Mr PeterH erbertf or technical assistanceM, S Julie Clyde for work on clonald ifferences and Dr C. S. Reilly for his usefulc omments.

Copyright 2014 Elsevier B.V., All rights reserved.


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