Effects of inhalational general anaesthetics on intact Daphnia magna (Cladocera: Crustacea)

J. Douglas McKenzre; Peter Calow; Walter S. Nimmo

doi:10.1016/0742-8413(92)90192-A

Effects of inhalational general anaesthetics on intact Daphnia magna (Cladocera: Crustacea)

J. Douglas McKenzre, Peter Calow, Walter S. Nimmo

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Abstract

1. The potency of general anaesthetics was studied in the water flea, Daphnia magna. 2. Anaesthesia was defined as a reversible lack of movement to stimulation with strong light. 3. ec₅₀s for methoxyflurane, halothane, isoflurane and enflurane were 0.095, 1.005, 1.170 and 1.422 (% v v in 100% oxygen). 4. Nitrous oxide had no significant additive effect on the ec₅₀s of the other agents, nor any effect on its own. 5. Oxygen concentrations in the carrier gas did not significantly affect the ec₅₀ of halothane. 6. Clonal differences in halothane potency were observed.

Original language	English (US)
Pages (from-to)	9-13
Number of pages	5
Journal	Comparative Biochemistry and Physiology. Part C, Comparative
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/0742-8413(92)90192-A
State	Published - Jan 1992
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgements-This work was supportedb y grants from the SheffieldU niversityR esearchF und and the Drug Absorption Foundation of Edinburgh.W e would like to thankM r Mark Cosgrovea nd Mr PeterH erbertf or technical assistanceM, S Julie Clyde for work on clonald ifferences and Dr C. S. Reilly for his usefulc omments.

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Copyright 2014 Elsevier B.V., All rights reserved.

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title = "Effects of inhalational general anaesthetics on intact Daphnia magna (Cladocera: Crustacea)",

abstract = "1. The potency of general anaesthetics was studied in the water flea, Daphnia magna. 2. Anaesthesia was defined as a reversible lack of movement to stimulation with strong light. 3. ec50s for methoxyflurane, halothane, isoflurane and enflurane were 0.095, 1.005, 1.170 and 1.422 (% v v in 100% oxygen). 4. Nitrous oxide had no significant additive effect on the ec50s of the other agents, nor any effect on its own. 5. Oxygen concentrations in the carrier gas did not significantly affect the ec50 of halothane. 6. Clonal differences in halothane potency were observed.",

author = "McKenzre, {J. Douglas} and Peter Calow and Nimmo, {Walter S.}",

note = "Funding Information: Acknowledgements-This work was supportedb y grants from the SheffieldU niversityR esearchF und and the Drug Absorption Foundation of Edinburgh.W e would like to thankM r Mark Cosgrovea nd Mr PeterH erbertf or technical assistanceM, S Julie Clyde for work on clonald ifferences and Dr C. S. Reilly for his usefulc omments. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1992",

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doi = "10.1016/0742-8413(92)90192-A",

language = "English (US)",

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T1 - Effects of inhalational general anaesthetics on intact Daphnia magna (Cladocera

T2 - Crustacea)

AU - McKenzre, J. Douglas

AU - Calow, Peter

AU - Nimmo, Walter S.

N1 - Funding Information: Acknowledgements-This work was supportedb y grants from the SheffieldU niversityR esearchF und and the Drug Absorption Foundation of Edinburgh.W e would like to thankM r Mark Cosgrovea nd Mr PeterH erbertf or technical assistanceM, S Julie Clyde for work on clonald ifferences and Dr C. S. Reilly for his usefulc omments. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1992/1

Y1 - 1992/1

N2 - 1. The potency of general anaesthetics was studied in the water flea, Daphnia magna. 2. Anaesthesia was defined as a reversible lack of movement to stimulation with strong light. 3. ec50s for methoxyflurane, halothane, isoflurane and enflurane were 0.095, 1.005, 1.170 and 1.422 (% v v in 100% oxygen). 4. Nitrous oxide had no significant additive effect on the ec50s of the other agents, nor any effect on its own. 5. Oxygen concentrations in the carrier gas did not significantly affect the ec50 of halothane. 6. Clonal differences in halothane potency were observed.

AB - 1. The potency of general anaesthetics was studied in the water flea, Daphnia magna. 2. Anaesthesia was defined as a reversible lack of movement to stimulation with strong light. 3. ec50s for methoxyflurane, halothane, isoflurane and enflurane were 0.095, 1.005, 1.170 and 1.422 (% v v in 100% oxygen). 4. Nitrous oxide had no significant additive effect on the ec50s of the other agents, nor any effect on its own. 5. Oxygen concentrations in the carrier gas did not significantly affect the ec50 of halothane. 6. Clonal differences in halothane potency were observed.

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JO - Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

JF - Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

IS - 1

ER -

Effects of inhalational general anaesthetics on intact Daphnia magna (Cladocera: Crustacea)

Abstract

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