Effects of in vivo T lymphocyte subset depletion on mycobacterial infections in mice

C. M. Flory, R. D. Hubbard, F. M. Collins

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48 Scopus citations

Abstract

The relative importance of CD4+ and CD8+ T cell subsets in the expression of acquired resistance to systemic infection by Mycobacterium kansasii was determined. T cell subsets were depleted in thymectomized C57BL/6 mice by the intravenous administration of monoclonal antibodies directed against the relevant T cell determinants. Depletion of the CD4+ subset exacerbated the severity of the infection in intravenously challenged mice. This effect was apparent in the first 2 weeks of the infection and persisted throughout the 12 weeks of the study. On the other hand, depletion of the CD8+ cells had no apparent effect on the growth curves. Infections by Mycobacterium tuberculosis Erdman or bacille Calmette-Guerin (BCG) Pasteur were also substantially enhanced by CD4 depletion, but not by the depletion of CD8+ cells. The effect of subset depletion on infections by M. tuberculosis and BCG was examined in both innately susceptible C57BL/6 mice and innately resistant B6D2 mice.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalJournal of Leukocyte Biology
Volume51
Issue number3
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • CD4
  • CD8
  • Mycobacterium kansasii
  • bacille Calmette-Guerin
  • immunity
  • tuberculosis

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