Effects of hypothyroidism on the response of the rat colon to morphine

J. Pablo Huidobro-Toro; R. Adron Harris; Horace H. Loh; E. Leong Way

doi:10.1016/0014-2999(78)90205-4

Effects of hypothyroidism on the response of the rat colon to morphine

J. Pablo Huidobro-Toro, R. Adron Harris, Horace H. Loh, E. Leong Way

Pharmacology

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Abstract

Isolated terminal colon strips obtained from rats, made hypothyroid by methimazole treatment, were almost completely insensitive to the contractile effects of morphine as compared to strips from control animals. This low morphine sensitivity was accompanied by a significant (40%) reduction in the tissue sulfatide content. Although colon strips from hypothyroid rats showed a reduction of the contractile effects of acetylcholine, the decrease was considerably less than that noted for morphine. The addition of 6.6 × 10^-5 M tri-iodothyronine to colons from hypothyroid rats largely restored the tissue sensitivity to morphine. These results suggest that sulfatides could be linked to the in vitro effects of morphine in the colon.

Original language	English (US)
Pages (from-to)	191-195
Number of pages	5
Journal	European Journal of Pharmacology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(78)90205-4
State	Published - Nov 15 1978

Keywords

Colon reactivity
Hypothyroidism
Methimazole treatment
Opiate effect
Sulfatide content

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10.1016/0014-2999(78)90205-4

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title = "Effects of hypothyroidism on the response of the rat colon to morphine",

abstract = "Isolated terminal colon strips obtained from rats, made hypothyroid by methimazole treatment, were almost completely insensitive to the contractile effects of morphine as compared to strips from control animals. This low morphine sensitivity was accompanied by a significant (40%) reduction in the tissue sulfatide content. Although colon strips from hypothyroid rats showed a reduction of the contractile effects of acetylcholine, the decrease was considerably less than that noted for morphine. The addition of 6.6 × 10-5 M tri-iodothyronine to colons from hypothyroid rats largely restored the tissue sensitivity to morphine. These results suggest that sulfatides could be linked to the in vitro effects of morphine in the colon.",

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T1 - Effects of hypothyroidism on the response of the rat colon to morphine

AU - Pablo Huidobro-Toro, J.

AU - Adron Harris, R.

AU - Loh, Horace H.

AU - Leong Way, E.

PY - 1978/11/15

Y1 - 1978/11/15

N2 - Isolated terminal colon strips obtained from rats, made hypothyroid by methimazole treatment, were almost completely insensitive to the contractile effects of morphine as compared to strips from control animals. This low morphine sensitivity was accompanied by a significant (40%) reduction in the tissue sulfatide content. Although colon strips from hypothyroid rats showed a reduction of the contractile effects of acetylcholine, the decrease was considerably less than that noted for morphine. The addition of 6.6 × 10-5 M tri-iodothyronine to colons from hypothyroid rats largely restored the tissue sensitivity to morphine. These results suggest that sulfatides could be linked to the in vitro effects of morphine in the colon.

AB - Isolated terminal colon strips obtained from rats, made hypothyroid by methimazole treatment, were almost completely insensitive to the contractile effects of morphine as compared to strips from control animals. This low morphine sensitivity was accompanied by a significant (40%) reduction in the tissue sulfatide content. Although colon strips from hypothyroid rats showed a reduction of the contractile effects of acetylcholine, the decrease was considerably less than that noted for morphine. The addition of 6.6 × 10-5 M tri-iodothyronine to colons from hypothyroid rats largely restored the tissue sensitivity to morphine. These results suggest that sulfatides could be linked to the in vitro effects of morphine in the colon.

KW - Colon reactivity

KW - Hypothyroidism

KW - Methimazole treatment

KW - Opiate effect

KW - Sulfatide content

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Effects of hypothyroidism on the response of the rat colon to morphine

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