Effects of hypothyroidism on the response of the rat colon to morphine

J. Pablo Huidobro-Toro, R. Adron Harris, Horace H. Loh, E. Leong Way

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Isolated terminal colon strips obtained from rats, made hypothyroid by methimazole treatment, were almost completely insensitive to the contractile effects of morphine as compared to strips from control animals. This low morphine sensitivity was accompanied by a significant (40%) reduction in the tissue sulfatide content. Although colon strips from hypothyroid rats showed a reduction of the contractile effects of acetylcholine, the decrease was considerably less than that noted for morphine. The addition of 6.6 × 10-5 M tri-iodothyronine to colons from hypothyroid rats largely restored the tissue sensitivity to morphine. These results suggest that sulfatides could be linked to the in vitro effects of morphine in the colon.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalEuropean Journal of Pharmacology
Volume52
Issue number2
DOIs
StatePublished - Nov 15 1978

Fingerprint

Hypothyroidism
Morphine
Colon
Sulfoglycosphingolipids
Methimazole
Acetylcholine

Keywords

  • Colon reactivity
  • Hypothyroidism
  • Methimazole treatment
  • Opiate effect
  • Sulfatide content

Cite this

Effects of hypothyroidism on the response of the rat colon to morphine. / Pablo Huidobro-Toro, J.; Adron Harris, R.; Loh, Horace H.; Leong Way, E.

In: European Journal of Pharmacology, Vol. 52, No. 2, 15.11.1978, p. 191-195.

Research output: Contribution to journalArticle

Pablo Huidobro-Toro, J. ; Adron Harris, R. ; Loh, Horace H. ; Leong Way, E. / Effects of hypothyroidism on the response of the rat colon to morphine. In: European Journal of Pharmacology. 1978 ; Vol. 52, No. 2. pp. 191-195.
@article{9809ab62a25e4b45b77cee97abd7a9e6,
title = "Effects of hypothyroidism on the response of the rat colon to morphine",
abstract = "Isolated terminal colon strips obtained from rats, made hypothyroid by methimazole treatment, were almost completely insensitive to the contractile effects of morphine as compared to strips from control animals. This low morphine sensitivity was accompanied by a significant (40{\%}) reduction in the tissue sulfatide content. Although colon strips from hypothyroid rats showed a reduction of the contractile effects of acetylcholine, the decrease was considerably less than that noted for morphine. The addition of 6.6 × 10-5 M tri-iodothyronine to colons from hypothyroid rats largely restored the tissue sensitivity to morphine. These results suggest that sulfatides could be linked to the in vitro effects of morphine in the colon.",
keywords = "Colon reactivity, Hypothyroidism, Methimazole treatment, Opiate effect, Sulfatide content",
author = "{Pablo Huidobro-Toro}, J. and {Adron Harris}, R. and Loh, {Horace H.} and {Leong Way}, E.",
year = "1978",
month = "11",
day = "15",
doi = "10.1016/0014-2999(78)90205-4",
language = "English (US)",
volume = "52",
pages = "191--195",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Effects of hypothyroidism on the response of the rat colon to morphine

AU - Pablo Huidobro-Toro, J.

AU - Adron Harris, R.

AU - Loh, Horace H.

AU - Leong Way, E.

PY - 1978/11/15

Y1 - 1978/11/15

N2 - Isolated terminal colon strips obtained from rats, made hypothyroid by methimazole treatment, were almost completely insensitive to the contractile effects of morphine as compared to strips from control animals. This low morphine sensitivity was accompanied by a significant (40%) reduction in the tissue sulfatide content. Although colon strips from hypothyroid rats showed a reduction of the contractile effects of acetylcholine, the decrease was considerably less than that noted for morphine. The addition of 6.6 × 10-5 M tri-iodothyronine to colons from hypothyroid rats largely restored the tissue sensitivity to morphine. These results suggest that sulfatides could be linked to the in vitro effects of morphine in the colon.

AB - Isolated terminal colon strips obtained from rats, made hypothyroid by methimazole treatment, were almost completely insensitive to the contractile effects of morphine as compared to strips from control animals. This low morphine sensitivity was accompanied by a significant (40%) reduction in the tissue sulfatide content. Although colon strips from hypothyroid rats showed a reduction of the contractile effects of acetylcholine, the decrease was considerably less than that noted for morphine. The addition of 6.6 × 10-5 M tri-iodothyronine to colons from hypothyroid rats largely restored the tissue sensitivity to morphine. These results suggest that sulfatides could be linked to the in vitro effects of morphine in the colon.

KW - Colon reactivity

KW - Hypothyroidism

KW - Methimazole treatment

KW - Opiate effect

KW - Sulfatide content

UR - http://www.scopus.com/inward/record.url?scp=0018226099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018226099&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(78)90205-4

DO - 10.1016/0014-2999(78)90205-4

M3 - Article

C2 - 729631

AN - SCOPUS:0018226099

VL - 52

SP - 191

EP - 195

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -