We hypothesized that high-intensity interval training (HIIT) would be more effective than moderate-intensity continuous training (MICT) at improving endothelial function and maximum oxygen uptake (V? O2 max) in obese adults. Eighteen participants [35.1 8.1 (SD) yr; body mass index 36.0 5.0 kg/m2] were randomized to 8 wk (3 sessions/wk) of either HIIT [10 1 min, 90-95% maximum heart rate (HRmax), 1-min active recovery] or MICT (30 min, 70-75% HRmax). Brachial artery flow-mediated dilation (FMD) increased after HIIT (5.13 2.80% vs. 8.98 2.86%, P<0.02) but not after MICT (5.23 2.82% vs. 3.05 2.76%, P<0.16). Resting artery diameter increased after MICT (3.68 0.58 mm vs. 3.86 0.58 mm, P<0.02) but not after HIIT (4.04 0.70 mm vs. 4.09 0.70 mm; P<0.63). There was a significant (P<0.02) group time interaction in low flowmediated constriction (L-FMC) between MICT (0.63 2.00% vs. 2.79 3.20%; P<0.03) and HIIT (1.04 4.09% vs. 1.74 3.46%; P<0.29). V ? O2 max increased (P-0.01) similarly after HIIT (2.19 0.65 l/min vs. 2.64 0.88 l/min) and MICT (2.24 0.48 l/min vs. 2.55 0.61 l/min). Biomarkers of cardiovascular risk and endothelial function were unchanged. HIIT and MICT produced different vascular adaptations in obese adults, with HIIT improving FMD and MICT increasing resting artery diameter and enhancing L-FMC. HIIT required 27.5% less total exercise time and 25% less energy expenditure than MICT.
Bibliographical noteFunding Information:
This study was supported by Arizona State University Graduate and Professional Student Association Research Grant. J. R. Ryder is supported by an individual training grant from National Heart, Lung, and Blood Institute (F32-HL127851-01).
Copyright © 2016 the American Physiological Society.
- Flow-mediated dilation
PubMed: MeSH publication types
- Journal Article