Effects of high-dose and low-dose preoperative irradiation on low anterior anastomoses in dogs

Melvin P. Bubrick, Eric S. Rolfsmeyer, Robert M. Schauer, Daniel A Feeney, Gary R. Johnston, Robert L. Strom, Claude R. Hitchcock

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Twenty mongrel dogs underwent preoperative irradiation to the colon and rectum, receiving 4000 rads according to the Nominal Standard Dose Equation. Each dog then underwent anterior resection of the rectosigmoid, and reconstructive technique was randomized into two groups consisting of either handsewn or EEA-stapled anastomoses. Anastomoses were examined digitally and radiographically at the time of surgery and on the seventh postoperative day. There were four radiographic leaks among the handsewn anastomoses, but only one was clinically significant and associated with peritonitis. There were no leaks among the ten EEA-stapled anastomoses. The data suggest that low anterior resection and anastomosis can be done safely after 4000 rad irradiation and that the EEA-stapled anastomosis may be preferable.

Original languageEnglish (US)
Pages (from-to)406-415
Number of pages10
JournalDiseases of the Colon & Rectum
Volume25
Issue number5
DOIs
StatePublished - Jul 1 1982

Keywords

  • Anastomosis
  • Carcinoma, Colon
  • Radiation therapy
  • Rectum
  • Stapling device

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