Effects of Hematopoietic Cell Transplantation on the Pulmonary Immune Response to Infection

Matt S. Zinter, Janet R. Hume

Research output: Contribution to journalReview articlepeer-review

Abstract

Pulmonary infections are common in hematopoietic cell transplant (HCT) patients of all ages and are associated with high levels of morbidity and mortality. Bacterial, viral, fungal, and parasitic pathogens are all represented as causes of infection. The lung mounts a complex immune response to infection and this response is significantly affected by the pre-HCT conditioning regimen, graft characteristics, and ongoing immunomodulatory therapy. We review the published literature, including animal models as well as human data, to describe what is known about the pulmonary immune response to infection in HCT recipients. Studies have focused on the pulmonary immune response to Aspergillus fumigatus, gram-positive and gram-negative bacteria, and viruses, and show a range of defects associated with both the innate and adaptive immune responses after HCT. There are still many open areas for research, to delineate novel therapeutic targets for pulmonary infections as well as to explore linkages to non-infectious inflammatory lung conditions.

Original languageEnglish (US)
Article number634566
JournalFrontiers in Pediatrics
Volume9
DOIs
StatePublished - Jan 26 2021

Bibliographical note

Funding Information:
MZ was funded by NHLBI K23HL146936. JH was funded by University of Minnesota Medical School Department of Pediatrics start-up funds.

Publisher Copyright:
© Copyright © 2021 Zinter and Hume.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

  • hematopoietic stem cell transplant
  • immune response
  • invasive aspergillosis
  • lung
  • pneumonia
  • pneumonitis
  • pulmonary immunity

PubMed: MeSH publication types

  • Journal Article
  • Review

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