Effects of fluvastatin (XU 62-320), an HMG-CoA reductase inhibitor, on the distribution and composition of low density lipoprotein subspecies in humans

Jiana Yuan, Michael Y Tsai, Janet Hegland, Donald B. Hunninghake

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

We studied the effect of fluvastatin (XU 62-320), a new HMG-CoA reductase inhibitor, on the distribution of low density lipoprotein (LDL) subspecies and composition in humans. As expected, fluvastatin significantly lowered serum LDL levels (25% after 6 weeks of therapy). In addition, treatment with fluvastatin changed the LDL subspecies. In the group treated with fluvastatin, 38.5% of the individuals showed changes in the shape of LDL absorbance profile obtained from density gradient ultracentrifugation and 54% of the group showed changes in the electrophoretic mobility of the LDL bands. Of those showing changes in electrophoretic mobility, the majority (78%) shifted to slightly larger, less dense LDL after drug therapy. However, the LDL-cholesterol/apo B ratio changes were relatively small in all fluvastatin-treated individuals including the group with changes in eletrophoretic mobility, confirming that HMG-CoA reductase inhibitor causes relatively small and subtle changes in the distribution of LDL subspecies.

Original languageEnglish (US)
Pages (from-to)147-157
Number of pages11
JournalAtherosclerosis
Volume87
Issue number2-3
DOIs
StatePublished - Apr 1991

Keywords

  • Electrophoresis
  • Fluvastatin
  • HMG-CoA reductase inhibitor
  • LDL subspecies
  • Ultracentrifugation

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