Effects of fenfluramine on EEG and brainstem average evoked response in infantile autism

N. Raz, W. S. Pritchard, Gerald August

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effects of fenfluramine on electrophysiological activity in autistic children were assessed by computerized EEG power analysis and brainstem evoked responses (SER). Prolonged administration of fenfluramine resulted in a decrease of relative share of α-waves in the EEG power spectrum and in corresponding increase in slow activity. No effects of the drug on BSER latencies were observed. The spectral EEG pattern of fenfluramine identified in this sample was compared to the spectra reported for normal volunteers on an acute dose of fenfluramine. The implications of these findings for EEG classification of fenfluramine and neurochemical mechanisms of autism are discussed.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalNeuropsychobiology
Volume18
Issue number2
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint Dive into the research topics of 'Effects of fenfluramine on EEG and brainstem average evoked response in infantile autism'. Together they form a unique fingerprint.

  • Cite this