Effects of ethanol on acetylcholine and GABA release: differences in the role of potassium.

R. Strong, C. Rehwaldt, W. G. Wood, A. Y. Sun, G. Y. Sun

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Ethanol inhibited electrically stimulated [3H]ACh release from cortical brain slices, but not when release was stimulated by high potassium. In contrast, ethanol was ineffective on electrically stimulated release of [14]GABA from cortical brain slices, but inhibited potassium-induced release. Ethanol also significantly inhibited potassium-stimulated [14C]GABA release from cortical synaptosomes. These data suggest that ethanol selectively inhibits GABA release from neurons by a specific effect on potassium conductance, and inhibits ACh release by a selective effect on Na+ conductance.

Original languageEnglish (US)
Pages (from-to)631-635
Number of pages5
JournalAlcohol and alcoholism (Oxford, Oxfordshire). Supplement.
Volume1
StatePublished - 1987

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