Effects of early-life adversity on cognitive decline in older African Americans and whites

Lisa L. Barnes, Robert S. Wilson, Susan Everson-Rose, Mark D. Hayward, Denis A. Evans, Carlos F.Mendes De Leon

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objectives: Early-life adversity is related to adult health in old age but little is known about its relation with cognitive decline. Methods: Participants includedmore than 6,100 older residents (mean age574.9 [7.1] years; 61.8% African American) enrolled in the Chicago Health and Aging Project, a geographically defined, population- based study of risk factors for Alzheimer disease. Participants were interviewed at approximately 3-year intervals for up to 16 years. The interview included a baseline evaluation of early-life adversity, and administration of 4 brief cognitive function tests to assess change in cognitive function. We estimated the relation of early-life adversity to rate of cognitive decline in a series of mixed-effectsmodels. Results: Inmodels stratified by race, and adjusted for age and sex, early-life adversitywas differentially related to decline in African Americans and whites. Whereas no measure of early-life adversity related to cognitive decline in whites, both food deprivation and being thinner than average in early life were associated with a slower rate of cognitive decline in African Americans. The relations were not mediated by years of education and persisted after adjustment for cardiovascular factors. Conclusions: Markers of early-life adversity had an unexpected protective effect on cognitive decline in African Americans.

Original languageEnglish (US)
Pages (from-to)2321-2327
Number of pages7
JournalNeurology
Volume79
Issue number24
DOIs
StatePublished - Dec 11 2012

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African Americans
Cognition
Food Deprivation
Health
Cognitive Dysfunction
Alzheimer Disease
Interviews
Education
Population

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Barnes, L. L., Wilson, R. S., Everson-Rose, S., Hayward, M. D., Evans, D. A., & De Leon, C. F. M. (2012). Effects of early-life adversity on cognitive decline in older African Americans and whites. Neurology, 79(24), 2321-2327. https://doi.org/10.1212/WNL.0b013e318278b607

Effects of early-life adversity on cognitive decline in older African Americans and whites. / Barnes, Lisa L.; Wilson, Robert S.; Everson-Rose, Susan; Hayward, Mark D.; Evans, Denis A.; De Leon, Carlos F.Mendes.

In: Neurology, Vol. 79, No. 24, 11.12.2012, p. 2321-2327.

Research output: Contribution to journalArticle

Barnes, Lisa L. ; Wilson, Robert S. ; Everson-Rose, Susan ; Hayward, Mark D. ; Evans, Denis A. ; De Leon, Carlos F.Mendes. / Effects of early-life adversity on cognitive decline in older African Americans and whites. In: Neurology. 2012 ; Vol. 79, No. 24. pp. 2321-2327.
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