Effects of drugs that modify brain monoamine concentrations on photoperiodically induced testicular growth in coturnix quail (Coturnix coturnix japonica)

M E Elhalawani, W. H. Burke, L. A. Ogren

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The monoamine oxide inhibitor tranylcypromine (TCP) increases brain dopamine (DA), norepinephrine (NE) and serotonin (5-HT) levels and inhibits photoperiodically-induced testicular growth in quail. Blockade of catecholamine synthesis by α-methyl-tyrosine (MT) in TCP treated quail preferentially elevates 5-HT levels and does not interfere with TCP inhibition of the gonads, however, treatment with parachlorophenylalanine (PCPA) reduces 5-HT and DA and antagonizes the action of TCP. Treatment with PCPA alone causes further augmentation of testicular response to photostimulation and reduces 5-HT and DA levels in the brain, whereas 5-hydroxytryptophan (5-HTP) administration elevates central 5-HT stores and partially inhibits testicular development. The results are consistent with the view that 5-HT may have an inhibitory effect on the process of gonadal development; in addition, an inhibitory influence of DA may also be involved.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalBiology of reproduction
Volume18
Issue number2
DOIs
StatePublished - 1978

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