Effects of drugs that modify brain monoamine concentrations on photoperiodically induced testicular growth in coturnix quail (Coturnix coturnix japonica)

M E Elhalawani, W. H. Burke, L. A. Ogren

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The monoamine oxide inhibitor tranylcypromine (TCP) increases brain dopamine (DA), norepinephrine (NE) and serotonin (5-HT) levels and inhibits photoperiodically-induced testicular growth in quail. Blockade of catecholamine synthesis by α-methyl-tyrosine (MT) in TCP treated quail preferentially elevates 5-HT levels and does not interfere with TCP inhibition of the gonads, however, treatment with parachlorophenylalanine (PCPA) reduces 5-HT and DA and antagonizes the action of TCP. Treatment with PCPA alone causes further augmentation of testicular response to photostimulation and reduces 5-HT and DA levels in the brain, whereas 5-hydroxytryptophan (5-HTP) administration elevates central 5-HT stores and partially inhibits testicular development. The results are consistent with the view that 5-HT may have an inhibitory effect on the process of gonadal development; in addition, an inhibitory influence of DA may also be involved.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalBiology of reproduction
Volume18
Issue number2
DOIs
StatePublished - Jan 1 1978

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Coturnix
Quail
Serotonin
Tranylcypromine
Brain
Growth
Dopamine
Pharmaceutical Preparations
5-Hydroxytryptophan
Gonads
Oxides
Catecholamines
Tyrosine
Norepinephrine

Cite this

Effects of drugs that modify brain monoamine concentrations on photoperiodically induced testicular growth in coturnix quail (Coturnix coturnix japonica). / Elhalawani, M E; Burke, W. H.; Ogren, L. A.

In: Biology of reproduction, Vol. 18, No. 2, 01.01.1978, p. 198-203.

Research output: Contribution to journalArticle

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