Effects of Dietary Tin and Copper on Rat Hepatocellular Antioxidant Protection

Marla Reicks, Jeanne I. Rader

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The effects of dietary tin on copper status and on enzymes and metabolites involved in hepatocellular antioxidant protection were measured in rats fed copper-adequate or copper-deficient diets with glucose or fructose. Rats became copper-depleted after 4 weeks on diets containing <0.5 μg of copper/g as evidenced by significant decreases in liver copper and serum ceruloplasmin. Signs of copper deficiency occurred in copper-depleted rats fed diets containing 100 μg of tin/g. Significant effects of tin on liver glutathione peroxidase and superoxide dismutase activities and on liver iron and total glutathione concentrations were observed. Interactions between copper and tin on liver copper and iron and on liver superoxide dismutase and malon-dialdehyde production are reported. Adverse effects of feeding diets containing 100 μg of tin/g include (i) copper depletion in rats fed copper-adequate diets, (ii) accelerated development of copper deficiency in rats fed copper-deficient diets, and (iii) reduction in hepatocellular antioxidant protection.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - Oct 1990


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