Effects of corticosteroids on responses of bovine peripheral blood lymphocytes cultured with phytohemagglutinin.

C. C. Muscoplat, R. E. Shope, A. W. Chen, D. W. Johnson

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Corticosteroids given in vivo altered the response of lymphocytes in the peripheral blood of calves. Lymphocytes were cultured and stimulated in vitro with phytohemagglutinin (PHA). After an initial suppression of lymphocyte responses to PHA, there was a rapid return to normal. It is concluded that, in calves, short-term, high-dose immunosuppressive therapy with corticosteroids produces a population of lymphocytes resistant to corticosteroids, possibly by destruction of corticosteroid-sensitive lymphocytes.

Original languageEnglish (US)
Pages (from-to)1243-1244
Number of pages2
JournalAmerican journal of veterinary research
Volume36
Issue number8
StatePublished - Aug 1 1975

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