Effects of coenzyme Q10 administration in amyotrophic lateral sclerosis (ALS). Report of a case and review

Terukazu Kawasaki, R. B. Singh, Germaine G Cornelissen-Guillaume, Franz Halberg

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Objective: Coenzyme Q10 (CoQ10) appears to be a promising agent in neurodegenerative disorders because they are associated with defects in the inner mitochondrial membrane and in oxidative phosphorylation. This report aims to highlight the role of CoQ10 in amyotrophic lateral sclerosis. Methods: A 75 year old medical scientist (1st author TK) unbiased for treatment with CoQ10, volunteered for CoQ10 ad-ministration. He himself recorded his symptoms, mood, sensations, body weight, using limb Norris score, hand grip power for both hands. He received highly bioavailable CoQ10 in a dose of 500 mg twice daily initially followed by 200mg twice daily for treatment in 2005. (solubilized ubiquinol, Tishcon Corp. NY). His plasma CoQ10 level was ob-tained initially and after treatment with CoQ10. Results: He presented with weakness of left leg along with cramps in the left calf muscle with steppage gate in September 2000. He had wasting of muscles, fasciculations and exaggerated reflexes. He had rapid deterioration in hand grip power in the left hand and weakness in left lower limb followed by right limbs with inability in walking and routine activities. Treatment with ubiquinol in 2005, resulted in better hand grip power, mood and sensation within a month and in 2006, he reported that hand grip power and wasting of muscles are not progressing as rapidly as before administering CoQ10. Interpretations: Treatment with highly solubilized ubiquinol can provide benefit to patients with ALS. Further controlled trials would be necessary to confirm our findings.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalOpen Nutraceuticals Journal
Volume5
Issue number1
DOIs
StatePublished - Dec 18 2012

Fingerprint

coenzyme Q10
Amyotrophic Lateral Sclerosis
case studies
hands
Hand
Hand Strength
limbs (animal)
emotions
Muscles
muscles
Extremities
Fasciculation
Therapeutics
Muscle Cramp
oxidative phosphorylation
amyotrophic lateral sclerosis
Oxidative Phosphorylation
neurodegenerative diseases
Mitochondrial Membranes
reflexes

Keywords

  • Diet
  • Motor Neuron Disease
  • Ubiquinol
  • Wasting of muscles

Cite this

Effects of coenzyme Q10 administration in amyotrophic lateral sclerosis (ALS). Report of a case and review. / Kawasaki, Terukazu; Singh, R. B.; Cornelissen-Guillaume, Germaine G; Halberg, Franz.

In: Open Nutraceuticals Journal, Vol. 5, No. 1, 18.12.2012, p. 187-192.

Research output: Contribution to journalReview article

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