Effects of carnosine on the evoked potentials in hippocampal CA1 region

Zhou Yan Feng, Xiao Jing Zheng, Jing Wang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: To directly examine the effects of carnosine on neuronal excitation and inhibition in rat hippocampus in vivo. Methods: Artificial cerebrospinal fluid with carnosine was directly administrated over the exposed rat hippocampus. The changes of neuron activity in the CA1 region of hippocampus were evaluated by orthodromically- and antidromically-evoked potentials, as well as paired-pulse stimulation paradigm. Results: In both orthodromic and antidromic response potentials, carnosine transformed population spikes (PSs) with single spike into epileptiform multiple spikes. In addition, similar to the effect of γ-aminobutyric acidA (GABAA) antagonist picrotoxin, carnosine decreased paired-pulse stimulating depression significantly. However, no significant change was observed in the spontaneous field potentials during the application of carnosine. Conclusion: The results indicate a disinhibition-induced excitation effect of carnosine on the CA1 pyramidal neurons. It provides important information against the application of carnosine as a potential anticonvulsant in clinical treatment.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalJournal of Zhejiang University: Science B
Issue number7
StatePublished - 2009
Externally publishedYes

Bibliographical note

Funding Information:
* Project (Nos. 30570585 and 30770548) supported by the National Natural Science Foundation of China


  • Carnosine
  • Epileptic seizure
  • Evoked potential
  • Hippocampus


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