Effects of carbamazepine on acute responses to smoked cocaine-base in human cocaine users

Dorothy Hatsukami, Robert Keenan, James Halikas, Paul R. Pentel, Lisa Hartman Brauer

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

A double-blind, placebo-controlled cross-over study was conducted to determine the effects of carbamazepine on the acute physiological and subjective responses to a single dose of smoked cocaine-base. Male cocaine users (N=6) were given 400 mg carbamazepine or placebo, each for a period of 5 days. At the end of the 5-day period, a 40 mg dose of smoked cocaine was administered. The results showed a significantly higher heart rate, diastolic blood pressure elevation, and blood pressure-heart rate product under the carbamazepine compared to the placebo condition. There were no effects of carbamazepine on the subjective responses from cocaine. The increase in cardiovascular functions indicates a need to be cautious in the use of carbamazepine in the treatment of cocaine abusers.

Original languageEnglish (US)
Pages (from-to)120-124
Number of pages5
JournalPsychopharmacology
Volume104
Issue number1
DOIs
StatePublished - May 1 1991

Keywords

  • Carbamazepine
  • Humans
  • Smoked cocaine

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