The effect of short-term caffeine withdrawal on lymphocyte beta -adrenoceptor sensitivity was studied in seven men who had been drinking coffee daily for at least 3 mo before the study. The ratio of cyclic adenosine monophosphate production after in vitro incubation with isoproterenol and a blank was used to assess receptor sensitivity. There was a reduction in sensitivity to isoproterenol but not to prostaglandin E, 3 days after caffeine withdrawal. The mechanism of this effect is not clear, but may represent a biochemical correlate of caffeine-withdrawal syndrome.
|Original language||English (US)|
|Number of pages||3|
|Journal||Clinical pharmacology and therapeutics|
|State||Published - Oct 1981|