Effects of caffeine withdrawal on isoproterenol-stimulated cyclic adenosine monophosphate

Thomas B. Mackenzie; Michael K Popkin; Joseph Dziubinski; John R. Sheppard

doi:10.1038/clpt.1981.185

Effects of caffeine withdrawal on isoproterenol-stimulated cyclic adenosine monophosphate

Thomas B. Mackenzie, Michael K Popkin, Joseph Dziubinski, John R. Sheppard

Medicine - Administration

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Abstract

The effect of short-term caffeine withdrawal on lymphocyte beta -adrenoceptor sensitivity was studied in seven men who had been drinking coffee daily for at least 3 mo before the study. The ratio of cyclic adenosine monophosphate production after in vitro incubation with isoproterenol and a blank was used to assess receptor sensitivity. There was a reduction in sensitivity to isoproterenol but not to prostaglandin E, 3 days after caffeine withdrawal. The mechanism of this effect is not clear, but may represent a biochemical correlate of caffeine-withdrawal syndrome.

Original language	English (US)
Pages (from-to)	436-438
Number of pages	3
Journal	Clinical pharmacology and therapeutics
Volume	30
Issue number	4
DOIs	https://doi.org/10.1038/clpt.1981.185
State	Published - Oct 1981

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abstract = "The effect of short-term caffeine withdrawal on lymphocyte beta -adrenoceptor sensitivity was studied in seven men who had been drinking coffee daily for at least 3 mo before the study. The ratio of cyclic adenosine monophosphate production after in vitro incubation with isoproterenol and a blank was used to assess receptor sensitivity. There was a reduction in sensitivity to isoproterenol but not to prostaglandin E, 3 days after caffeine withdrawal. The mechanism of this effect is not clear, but may represent a biochemical correlate of caffeine-withdrawal syndrome.",

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AB - The effect of short-term caffeine withdrawal on lymphocyte beta -adrenoceptor sensitivity was studied in seven men who had been drinking coffee daily for at least 3 mo before the study. The ratio of cyclic adenosine monophosphate production after in vitro incubation with isoproterenol and a blank was used to assess receptor sensitivity. There was a reduction in sensitivity to isoproterenol but not to prostaglandin E, 3 days after caffeine withdrawal. The mechanism of this effect is not clear, but may represent a biochemical correlate of caffeine-withdrawal syndrome.

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Effects of caffeine withdrawal on isoproterenol-stimulated cyclic adenosine monophosphate

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