Effects of caffeine withdrawal on isoproterenol-stimulated cyclic adenosine monophosphate

Thomas B. Mackenzie, Michael K Popkin, Joseph Dziubinski, John R. Sheppard

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The effect of short-term caffeine withdrawal on lymphocyte beta -adrenoceptor sensitivity was studied in seven men who had been drinking coffee daily for at least 3 mo before the study. The ratio of cyclic adenosine monophosphate production after in vitro incubation with isoproterenol and a blank was used to assess receptor sensitivity. There was a reduction in sensitivity to isoproterenol but not to prostaglandin E, 3 days after caffeine withdrawal. The mechanism of this effect is not clear, but may represent a biochemical correlate of caffeine-withdrawal syndrome.

Original languageEnglish (US)
Pages (from-to)436-438
Number of pages3
JournalClinical pharmacology and therapeutics
Issue number4
StatePublished - Oct 1981


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