Effects of autogenic training and antihypertensive agents on circadian and circaseptan variation of blood pressure

Yoshihiko Watanabe, Germaine G Cornelissen-Guillaume, Misako Watanabe, Fumihiko Watanabe, Kuniaki Otsuka, Shi Ichiro Ohkawa, Takenori Kikuchi, Franz Halberg

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Even when the daily blood pressure mean is acceptable, too large a circadian amplitude of blood pressure largely increases cardiovascular disease risk. Autogenic training (N = 11), a non-pharmacologic intervention capable of lowering an excessive blood pressure variability, may be well-suited for MESOR-normotensive patients diagnosed with circadian-hyper-amplitude-tension (CHAT). Not all anti-hypertensive drugs affect blood pressure variability. Accordingly, long-acting carteolol (N = 11) and/or atenolol (N = 8) may be preferred to captopril retard (N = 13), nilvadipine (N = 8), or amlodipine (N = 7) for midline-estimating statistic of rhythm (MESOR)-hypertensive patients with CHAT. Prospective outcome studies are needed to assess whether the relative merits of these treatments are in keeping with their effects on blood pressure and blood pressure variability.

Original languageEnglish (US)
Pages (from-to)405-412
Number of pages8
JournalClinical and Experimental Hypertension
Volume25
Issue number7
DOIs
StatePublished - Oct 1 2003

Keywords

  • Blood pressure variability
  • CHAT (circadian-hyper-amplitude-tension)
  • Cardiovascular disease risk
  • Non-pharmacologic vs. pharmacologic intervention

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