Effects of angiotensin II receptor blockade by [Sar1-Ala8]angiotensin II in hemorrhagic shock

G. J. Trachte, A. M. Lefer

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Abstract

An angiotensin II receptor antagonist, [Sar1-Ala8]angiotensin II (saralasin), was infused at 60 (μg/kg)/hr into cats to examine its effect in hemorrhagic shock. Aprotinin (1,000 (KIU/kg)/hr) was also administered to cats to determine how kinin inhibition effects angiotensin receptor blockade in shock. Saralasin was infused into shocked and sham-shocked cats. Aprotinin was administered to additional cats receiving either saralasin or its vehicle. Hemorrhaged cats treated with saralasin revealed a postoligemic preservation of mean arterial blood pressure and superior mesenteric artery blood flow (SMAF). Final pressures were 48 ± 12 mmHg and 81 ± 9 mmHg with vehicle and saralasin treatment, respectively, and final SMAF were 2.5 ± 0.5 (ml/kg)/min in cats receiving vehicle and 5.5 ± 0.6 (ml/kg)/min in those receiving saralasin. Total plasma proteolysis was diminished by both saralasin and aprotinin, exhibiting elevations of free amino-nitrogen groups of 2.5-fold and 2-fold over initial as compared to a 3.5-fold elevation in vehicle-treated shocked cats. Myocardial depression factor (MDF) activities were also suppressed by saralasin compared to shocked cats receiving vehicle (24 ± 4 units vs. 59 ± 3 units). These results indicate that blockade of angiotensin II actions in hemorrhagic shock is beneficial.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume5
Issue number2
StatePublished - Jan 1 1979

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