Effects of an indolocarbazole-derived CDK4 inhibitor on breast cancer cells

Keyphrases

• Breast Cancer Cells 100%
• Cyclin-dependent Kinase 4 (CDK4) 100%
• Indolocarbazole 100%
• CDK4 Inhibitors 100%
• Protein Level 80%
• Phosphorylation 60%
• P27Kip1 60%
• Cyclin-dependent Kinase 2 (CDK2) 40%
• Cyclin E 40%
• IC50 40%
• P21Cip1 40%
• MCF-7 40%
• Growth Arrest 40%
• Breast Cancer Cell Lines 40%
• Rb Protein 40%
• Gene Expression 20%
• Holoenzyme 20%
• Cell-to-cell 20%
• Cell Death 20%
• Apoptosis 20%
• Cyclin D1 (CCND1) 20%
• Cancer Chemotherapy 20%
• Sigma Phase 20%
• Cell Cycle Progression 20%
• Reverse Transcription 20%
• Western Blot 20%
• MRNA Level 20%
• Good Strategies 20%
• Acridine Orange 20%
• MDA-MB-231 20%
• T47D 20%
• Pyrrol 20%
• Dione 20%
• Bromus Inermis 20%
• Reverse PCR 20%
• Cyclin-dependent Kinase 6 (CDK6) 20%
• Deat 20%
• Carbazole 20%
• Cell Cycle Profile 20%
• Protein Complex Formation 20%
• MTT Assay 20%
• Clonogenic Assay 20%
• Co-immunoprecipitation (co-IP) 20%
• Proof of Concept Study 20%

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 100%
• IC50 50%
• Cyclin E 50%
• Cyclin-Dependent Kinase 50%
• Retinoblastoma Protein 50%
• CDKN1B 50%
• Western Blot 25%
• Immunoprecipitation 25%
• Acridine Orange 25%
• Gene Expression 25%
• S Phase 25%
• Protein Complexes 25%
• Single Drug Dose 25%
• Reverse Transcription 25%
• Cell Cycle 25%
• Cell Cycle Progression 25%
• Complex Formation 25%
• Fluorescence Activated Cell Sorting 25%
• Clonogenic Assay 25%
• Cell Death 25%
• High-Performance Liquid Chromatography 25%
• Cyclin D1 25%
• Cyclin-Dependent Kinase 4 25%
• Cyclin-Dependent Kinase 6 25%
• MTT Assay 25%
• Messenger RNA 25%
• Bromus 25%
• Programmed Cell Death 25%