Effects of amrinone on cardiac index, venous oxygen saturation and venous admixture in patients recovering from cardiac surgery

R. C. Prielipp, J. F. Butterworth, G. P. Zaloga, P. G. Robertie, R. L. Royster

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The hemodynamic and oxygen transport effects of low-dose (0.75 mg/kg loading dose + 10 μg/kg/min infusion, n = 12) and high-dose (2.25 mg/kg loading dose + 20 μg/kg/min infusion, n = 12) amrinone were evaluated in extubated patients 24 h after CABG. At both doses, amrinone significantly (p<0.05) increased HR, but decreased mean arterial, mean pulmonary artery, central venous and pulmonary artery occlusion pressures. High-dose amrinone significantly decreased systemic vascular resistance. Arterial oxygen saturation decreased significantly following both low- (97.8±0.4 to 95.6±0.9 percent) and high- (98.8±3.4 to 93.9±1.2 percent) dose amrinone. Pulmonary shunt increased significantly following low-dose amrinone and markedly increased Qs/Qt after high-dose amrinone. Although amrinone significantly increased cardiac index in a dose-dependent fashion (low:3.0±0.2 to 3.3±0.3 L/min/m2; high:2.7±0.2 to 3.4±0.2 L/min/m2), mixed venous oxygen saturation did not change. Thus, mixed venous oxygen saturation may not predict the hemodynamic response to amrinone infusion in postoperative surgical patients.

Original languageEnglish (US)
Pages (from-to)820-825
Number of pages6
JournalCHEST
Volume99
Issue number4
DOIs
StatePublished - 1991

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