TY - JOUR
T1 - Effects of Allyl Methyl Trisulfide on Glutathione 5-Transferase Activity and BP-Induced Neoplasia in the Mouse
AU - Sparnins, Velta L.
AU - Mott, Andrew W.
AU - Barany, George
AU - Wattenberg, Lee W.
N1 - Funding Information:
This work was supported by Grant SIG-5 from the American Cancer Society (to L.W. Wattenberg) and Grants GM-28934 and AM-01099 from the National Institutes of Health (to G. Barany).
PY - 1986/1/1
Y1 - 1986/1/1
N2 - Allyl methyl trisulfide (AMT), a constituent of garlic oil, was studied for its effects on glutathione S-transferase (GST) activity and on benzofa. Jpyrene (BP)-induced neoplasia of the forestomach and lungs of female A/J mice. AMT induced increased GST activity in the forestomach, small bowel mucosa, liver, and lung. The forestomach and small bowel mucosa responded to a single low dose of AMT (3.0 pmol) given by oral intubation, whereas liver and lung were less reactive. A dose schedule of two administrations of 15 pmol AMT given 48 hours apart gave close-to-maximum induction in all four tissues and was chosen for investigation of its inhibitory effects. With this dose schedule, AMTproduced an inhibition ofBP-induced neoplasia of the forestomach as shown by a greater than 70% reduction in the number of tumors found at the completion of the experiment. Inhibition of pulmonary neoplasia did not occur. AMT is a member of a new class of naturally occurring chemicals that have the capacity to inhibit chemical carcinogenesis.
AB - Allyl methyl trisulfide (AMT), a constituent of garlic oil, was studied for its effects on glutathione S-transferase (GST) activity and on benzofa. Jpyrene (BP)-induced neoplasia of the forestomach and lungs of female A/J mice. AMT induced increased GST activity in the forestomach, small bowel mucosa, liver, and lung. The forestomach and small bowel mucosa responded to a single low dose of AMT (3.0 pmol) given by oral intubation, whereas liver and lung were less reactive. A dose schedule of two administrations of 15 pmol AMT given 48 hours apart gave close-to-maximum induction in all four tissues and was chosen for investigation of its inhibitory effects. With this dose schedule, AMTproduced an inhibition ofBP-induced neoplasia of the forestomach as shown by a greater than 70% reduction in the number of tumors found at the completion of the experiment. Inhibition of pulmonary neoplasia did not occur. AMT is a member of a new class of naturally occurring chemicals that have the capacity to inhibit chemical carcinogenesis.
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U2 - 10.1080/01635588609513895
DO - 10.1080/01635588609513895
M3 - Article
C2 - 3737423
AN - SCOPUS:0022512295
VL - 8
SP - 211
EP - 215
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 3
ER -
