Effects of Allyl Methyl Trisulfide on Glutathione 5-Transferase Activity and BP-Induced Neoplasia in the Mouse

Velta L. Sparnins, Andrew W. Mott, George Barany, Lee W. Wattenberg

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112 Scopus citations

Abstract

Allyl methyl trisulfide (AMT), a constituent of garlic oil, was studied for its effects on glutathione S-transferase (GST) activity and on benzofa. Jpyrene (BP)-induced neoplasia of the forestomach and lungs of female A/J mice. AMT induced increased GST activity in the forestomach, small bowel mucosa, liver, and lung. The forestomach and small bowel mucosa responded to a single low dose of AMT (3.0 pmol) given by oral intubation, whereas liver and lung were less reactive. A dose schedule of two administrations of 15 pmol AMT given 48 hours apart gave close-to-maximum induction in all four tissues and was chosen for investigation of its inhibitory effects. With this dose schedule, AMTproduced an inhibition ofBP-induced neoplasia of the forestomach as shown by a greater than 70% reduction in the number of tumors found at the completion of the experiment. Inhibition of pulmonary neoplasia did not occur. AMT is a member of a new class of naturally occurring chemicals that have the capacity to inhibit chemical carcinogenesis.

Original languageEnglish (US)
Pages (from-to)211-215
Number of pages5
JournalNutrition and Cancer
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1986

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