Effects of acute and multiple dose administration of Sumithion (O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothionate) on some enzymes of Periplaneta americana (Linn.)

R. Sengupta, S. Basak, D. Sarkar, J. J. Ghosh

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Abstract

Acute exposure to Sumithion (65.0 μg/g dose) causes significant inhibition of acetylcholinesterase (AChE) in the digestive tissue of adult P. americana. At this dose there is practically no effect on the activities of either acid or alkaline phosphatases or non-specific esterases. Exposures to multiple doses of 1.3 μg/g at intervals of 24 and 48 hr, respectively, lower AChE activity by approximately 40%. On the other hand multiple doses cause an initial rise in the activities of phosphatases, indicating their possible involvement in the metabolism of the pesticide. However, later on, there is a decrease in levels of acid and alkaline phosphatase activities. This is coupled with a steady rise in nonspecific esterase activity indicating a possible take over of metabolizing role by these enzymes.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalPesticide Biochemistry and Physiology
Volume5
Issue number1
DOIs
StatePublished - Feb 1975
Externally publishedYes

Bibliographical note

Funding Information:
Thanks are forwarded to the Council of Scientific and Industrial Research Grant 13(6685)-70 Pool and the University of Calcutta for financing the invest,igations.

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