Effector mechanisms of humoral immunity to porcine reproductive and respiratory syndrome virus

Michael C. Rahe, Michael P. Murtaugh

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Porcine reproductive and respiratory syndrome virus (PRRSV) continues to afflict swine nearly 30 years after it was first discovered as the causative agent of “mystery swine disease”. Immunological tools of vaccination and exposure to virulent viruses have not succeeded in achieving control and prevention of PRRSV. Humoral immunity, mediated by antibodies, is a hallmark of anti-viral immunity, but little is known about the effector mechanisms of humoral immunity against PRRSV. It is essential to understand the immunological significance of antibody functions, including recently described broadly neutralizing antibodies and potential non-neutralizing activities, in the immune response to PRRSV. Here, we review recent research from PRRSV and other host-pathogen interactions to inform novel routes of exploration into PRRSV humoral immunity which may be important for identifying the immunological correlates of protection against PRRSV infection.

Original languageEnglish (US)
Pages (from-to)15-18
Number of pages4
JournalVeterinary immunology and immunopathology
StatePublished - Apr 1 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.


  • Antibody function
  • B cell
  • Humoral immunity
  • Neutralizing antibody


Dive into the research topics of 'Effector mechanisms of humoral immunity to porcine reproductive and respiratory syndrome virus'. Together they form a unique fingerprint.

Cite this