TY - JOUR
T1 - Effectiveness of a care bundle for primary prevention of intraventricular hemorrhage in high-risk neonates
T2 - a Bayesian analysis
AU - al-Haddad, Benjamin J.S.
AU - Bergam, Brittany
AU - Johnson, Alicia
AU - Kolnik, Sarah
AU - Thompson, Taylor
AU - Perez, Krystle M.
AU - Kennedy, Jacob
AU - Enquobahrie, Daniel A.
AU - Juul, Sandra E.
AU - German, Kendell
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2023/6
Y1 - 2023/6
N2 - Objective: To determine whether an intraventricular hemorrhage (IVH) prevention bundle featuring midline-elevated positioning reduced IVH among high-risk infants. Study design: In a retrospective study design, we compared outcomes of infants <1250 grams birth weight or <30 weeks gestation before (N = 205) and after (N = 360) implementation of an IVH prevention bundle, using Bayesian and frequentist logistic regression to determine whether the intervention decreased any grade IVH. Results: In both the Bayesian and frequentist analyses, there was no difference in odds of any grade IVH before and after the implementation of the prevention bundle (OR 0.993; 95% Credible Interval 0.751–1.323 and OR 1.23; 95% Confidence Interval 0.818–1.864 respectively). Bias analyses suggested that these results were robust to bias from potential deaths attributable to IVH. Conclusion: In this retrospective analysis, we found no evidence for a protective effect of an IVH prevention bundle on IVH incidence among high-risk neonates at a level IV NICU.
AB - Objective: To determine whether an intraventricular hemorrhage (IVH) prevention bundle featuring midline-elevated positioning reduced IVH among high-risk infants. Study design: In a retrospective study design, we compared outcomes of infants <1250 grams birth weight or <30 weeks gestation before (N = 205) and after (N = 360) implementation of an IVH prevention bundle, using Bayesian and frequentist logistic regression to determine whether the intervention decreased any grade IVH. Results: In both the Bayesian and frequentist analyses, there was no difference in odds of any grade IVH before and after the implementation of the prevention bundle (OR 0.993; 95% Credible Interval 0.751–1.323 and OR 1.23; 95% Confidence Interval 0.818–1.864 respectively). Bias analyses suggested that these results were robust to bias from potential deaths attributable to IVH. Conclusion: In this retrospective analysis, we found no evidence for a protective effect of an IVH prevention bundle on IVH incidence among high-risk neonates at a level IV NICU.
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U2 - 10.1038/s41372-022-01545-9
DO - 10.1038/s41372-022-01545-9
M3 - Article
C2 - 36309564
AN - SCOPUS:85140956880
SN - 0743-8346
VL - 43
SP - 722
EP - 727
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 6
ER -