Effect size of reference memory deficits in the Morris water maze in Tg2576 mice

Miranda N. Reed; Peng Liu; Linda A. Kotilinek; Karen H. Ashe

doi:10.1016/j.bbr.2010.03.037

Effect size of reference memory deficits in the Morris water maze in Tg2576 mice

Miranda N. Reed, Peng Liu, Linda A. Kotilinek, Karen H. Ashe

Neurology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The most widely used mouse model of Alzheimer's disease is the Tg2576 (APP_SWE) model. While general agreement about their neuropathology prevails, disparate results concerning cognitive changes have been reported. To resolve this controversy, we combined Morris water maze data collected over >10 years to determine the extent of memory impairment. APP_SWE mice exhibited an age-dependent decline in memory, but the effect size was small when compared to non-transgenic littermates. Larger effect sizes were achieved when comparing APP_SWE and Tg5469 (APP_WT) mice.

Original language	English (US)
Pages (from-to)	115-120
Number of pages	6
Journal	Behavioural Brain Research
Volume	212
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2010.03.037
State	Published - Sep 2010

Keywords

Alzheimer's disease
Effect size
Morris water maze
Sample size
Tg2576

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10.1016/j.bbr.2010.03.037

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title = "Effect size of reference memory deficits in the Morris water maze in Tg2576 mice",

abstract = "The most widely used mouse model of Alzheimer's disease is the Tg2576 (APPSWE) model. While general agreement about their neuropathology prevails, disparate results concerning cognitive changes have been reported. To resolve this controversy, we combined Morris water maze data collected over >10 years to determine the extent of memory impairment. APPSWE mice exhibited an age-dependent decline in memory, but the effect size was small when compared to non-transgenic littermates. Larger effect sizes were achieved when comparing APPSWE and Tg5469 (APPWT) mice.",

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AU - Liu, Peng

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AU - Ashe, Karen H.

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KW - Morris water maze

KW - Sample size

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Effect size of reference memory deficits in the Morris water maze in Tg2576 mice

Abstract

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