Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats

Prashant Kumar Rai; Dolly Jaiswal; Devendra K. Rai; Bechan Sharma; Geeta Watal

doi:10.1007/s12291-008-0085-4

Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats

Prashant Kumar Rai, Dolly Jaiswal, Devendra K. Rai, Bechan Sharma, Geeta Watal

Veterinary Population Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein and body weight was increased. No toxic effect was observed during LD ₅₀. Our study suggests that further detailed toxicity studies and mechanism of action of T. dioica would be useful for undertaking human trials.

Original language	English (US)
Pages (from-to)	387-390
Number of pages	4
Journal	Indian Journal of Clinical Biochemistry
Volume	23
Issue number	4
DOIs	https://doi.org/10.1007/s12291-008-0085-4
State	Published - 2008

Bibliographical note

Funding Information:
The authors are grateful to NMPB (National Medicinal Plants Board), New Delhi, ICMR and CSIR for providing the financial assistance.

Keywords

Antidiabetic effect
Hepatoprotective
Trichosanthes dioica

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12291-008-0085-4

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abstract = "In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein and body weight was increased. No toxic effect was observed during LD 50. Our study suggests that further detailed toxicity studies and mechanism of action of T. dioica would be useful for undertaking human trials.",

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T1 - Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats

AU - Rai, Prashant Kumar

AU - Jaiswal, Dolly

AU - Rai, Devendra K.

AU - Sharma, Bechan

AU - Watal, Geeta

N1 - Funding Information: The authors are grateful to NMPB (National Medicinal Plants Board), New Delhi, ICMR and CSIR for providing the financial assistance.

PY - 2008

Y1 - 2008

N2 - In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein and body weight was increased. No toxic effect was observed during LD 50. Our study suggests that further detailed toxicity studies and mechanism of action of T. dioica would be useful for undertaking human trials.

AB - In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein and body weight was increased. No toxic effect was observed during LD 50. Our study suggests that further detailed toxicity studies and mechanism of action of T. dioica would be useful for undertaking human trials.

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KW - Hepatoprotective

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Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats

Abstract

Bibliographical note

Keywords

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