Effect of verapamil (isoptin) on experimental myocardial infarction in rhesus monkeys

R. N. Chakravarti, P. L. Sharma, I. S. Anand, P. A. Manga, P. L. Wahi

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Experimental myocardial infarction was produced in rhesus monkeys by ligating the anterior descending branch (LAD) of the left coronary artery. Verapamil was administered orally and intravenously to separate groups of 6 monkeys each and the effect of the drug on gross infarct size and light microscopic morphology of the infarct were analysed. There was a significant reduction in the gross infarct size in the treated animals as compared to the controls. Histopathological study revealed that in the verapamil treated group the healing process was enhanced in the infarcted zone of the myocardium, as compared to the controls.

Original languageEnglish (US)
Pages (from-to)625-632
Number of pages8
JournalIndian Journal of Medical Research
Volume73
Issue number4
StatePublished - Dec 1 1981

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