Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon

Miranda R. Bertram; Amy Delgado; Steven J. Pauszek; George R. Smoliga; Barbara Brito; Carolina Stenfeldt; Ethan J. Hartwig; Simon Dickmu Jumbo; Mamoudou Abdoulmoumini; Amba Abona Oliva Marie; Robert Salhine; Luis L. Rodriguez; Rebecca Garabed; Jonathan Arzt

doi:10.1016/j.prevetmed.2018.04.003

Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon

Miranda R. Bertram
, Amy Delgado
, Steven J. Pauszek
, George R. Smoliga
, Barbara Brito
, Carolina Stenfeldt
, Ethan J. Hartwig
, Simon Dickmu Jumbo
, Mamoudou Abdoulmoumini
, Amba Abona Oliva Marie
, Robert Salhine
, Luis L. Rodriguez
, Rebecca Garabed
, Jonathan Arzt

Veterinary Population Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Foot-and-mouth disease (FMD) is one of the most contagious and economically important livestock diseases worldwide. Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) was recently introduced in 2014. The objective of this study was to characterize vaccine performance in cattle under natural hyperendemic conditions in the Adamawa region of Cameroon. Vaccinated cattle (n = 50) and non-vaccinated controls (n = 100) were monitored by serum and oropharyngeal fluid (OPF) sample collection through a 12-month period. Anti-FMDV non-structural protein (anti-NSP) seroprevalence increased from 59.3% (89/150) at the beginning of the study to 85.8% (103/120) at the end of the study, and FMDV RNA was found in 28% (42/150) of animals overall, despite detection of clinical signs of FMD in only 6 non-vaccinated animals. Viral sequence analysis indicated that subclinical infections of FMDV serotypes O and A were present within the study herds during the study period, which was reflected by an overall increase of anti-NSP seroprevalence during the study. There was no association between vaccination status and seroconversion or prevalence of FMDV RNA in OPF. Younger cattle had higher odds of detection of FMDV RNA in OPF, but older animals were more likely to be seropositive. This study suggests vaccination of herds previously exposed to FMDV may help to limit clinical signs and reduce economic losses caused by FMDV. These findings also suggest that subclinical circulation of FMDV occurs in hyperendemic regions regardless of vaccination.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Preventive Veterinary Medicine
Volume	155
DOIs	https://doi.org/10.1016/j.prevetmed.2018.04.003
State	Published - Jul 1 2018

Bibliographical note

Funding Information:
This work was supported in part by ARS-CRIS project 1940-32000-061-00D and by a Cooperative Agreement from the United States Department of Agriculture’s Animal and Plant Health Inspection Service (APHIS) . Additional funding was provided by the U.S. Department of State, Biosecurity Engagement Program through the USDA , ARS Office of International Research Programs .

Funding Information:
Miranda Bertram and Barbara Brito were the recipients of a Plum Island Animal Disease Center Research Participation Program fellowship, administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy (DOE) and the U.S. Department of Agriculture (USDA). All opinions expressed in this paper are the authors’ and do not necessarily reflect the policies and views of the USDA, APHIS, DOE, or ORAU/ORISE. We thank Kuate Wafo Borrel Vicky for his assistance collecting samples in the field. We acknowledge the Institute of Agriculture Research for Development (IRAD), Cameroon, and the School of Sciences and Veterinary Medicine (ESMV) of Ngaoundéré.

Publisher Copyright:
© 2018

Keywords

Cameroon
FMD
Foot-and-mouth disease
Transboundary
Vaccination
Virus

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10.1016/j.prevetmed.2018.04.003

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Bertram, M. R., Delgado, A., Pauszek, S. J., Smoliga, G. R., Brito, B., Stenfeldt, C., Hartwig, E. J., Jumbo, S. D., Abdoulmoumini, M., Oliva Marie, A. A., Salhine, R., Rodriguez, L. L., Garabed, R., & Arzt, J. (2018). Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon. Preventive Veterinary Medicine, 155, 1-10. https://doi.org/10.1016/j.prevetmed.2018.04.003

Bertram, MR, Delgado, A, Pauszek, SJ, Smoliga, GR, Brito, B, Stenfeldt, C, Hartwig, EJ, Jumbo, SD, Abdoulmoumini, M, Oliva Marie, AA, Salhine, R, Rodriguez, LL, Garabed, R & Arzt, J 2018, 'Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon', Preventive Veterinary Medicine, vol. 155, pp. 1-10. https://doi.org/10.1016/j.prevetmed.2018.04.003

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title = "Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon",

abstract = "Foot-and-mouth disease (FMD) is one of the most contagious and economically important livestock diseases worldwide. Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) was recently introduced in 2014. The objective of this study was to characterize vaccine performance in cattle under natural hyperendemic conditions in the Adamawa region of Cameroon. Vaccinated cattle (n = 50) and non-vaccinated controls (n = 100) were monitored by serum and oropharyngeal fluid (OPF) sample collection through a 12-month period. Anti-FMDV non-structural protein (anti-NSP) seroprevalence increased from 59.3\% (89/150) at the beginning of the study to 85.8\% (103/120) at the end of the study, and FMDV RNA was found in 28\% (42/150) of animals overall, despite detection of clinical signs of FMD in only 6 non-vaccinated animals. Viral sequence analysis indicated that subclinical infections of FMDV serotypes O and A were present within the study herds during the study period, which was reflected by an overall increase of anti-NSP seroprevalence during the study. There was no association between vaccination status and seroconversion or prevalence of FMDV RNA in OPF. Younger cattle had higher odds of detection of FMDV RNA in OPF, but older animals were more likely to be seropositive. This study suggests vaccination of herds previously exposed to FMDV may help to limit clinical signs and reduce economic losses caused by FMDV. These findings also suggest that subclinical circulation of FMDV occurs in hyperendemic regions regardless of vaccination.",

keywords = "Cameroon, FMD, Foot-and-mouth disease, Transboundary, Vaccination, Virus",

author = "Bertram, \{Miranda R.\} and Amy Delgado and Pauszek, \{Steven J.\} and Smoliga, \{George R.\} and Barbara Brito and Carolina Stenfeldt and Hartwig, \{Ethan J.\} and Jumbo, \{Simon Dickmu\} and Mamoudou Abdoulmoumini and \{Oliva Marie\}, \{Amba Abona\} and Robert Salhine and Rodriguez, \{Luis L.\} and Rebecca Garabed and Jonathan Arzt",

note = "Funding Information: This work was supported in part by ARS-CRIS project 1940-32000-061-00D and by a Cooperative Agreement from the United States Department of Agriculture{\textquoteright}s Animal and Plant Health Inspection Service (APHIS) . Additional funding was provided by the U.S. Department of State, Biosecurity Engagement Program through the USDA , ARS Office of International Research Programs . Funding Information: Miranda Bertram and Barbara Brito were the recipients of a Plum Island Animal Disease Center Research Participation Program fellowship, administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy (DOE) and the U.S. Department of Agriculture (USDA). All opinions expressed in this paper are the authors{\textquoteright} and do not necessarily reflect the policies and views of the USDA, APHIS, DOE, or ORAU/ORISE. We thank Kuate Wafo Borrel Vicky for his assistance collecting samples in the field. We acknowledge the Institute of Agriculture Research for Development (IRAD), Cameroon, and the School of Sciences and Veterinary Medicine (ESMV) of Ngaound{\'e}r{\'e}. Publisher Copyright: {\textcopyright} 2018",

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T1 - Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon

AU - Bertram, Miranda R.

AU - Delgado, Amy

AU - Pauszek, Steven J.

AU - Smoliga, George R.

AU - Brito, Barbara

AU - Stenfeldt, Carolina

AU - Hartwig, Ethan J.

AU - Jumbo, Simon Dickmu

AU - Abdoulmoumini, Mamoudou

AU - Oliva Marie, Amba Abona

AU - Salhine, Robert

AU - Rodriguez, Luis L.

AU - Garabed, Rebecca

AU - Arzt, Jonathan

N1 - Funding Information: This work was supported in part by ARS-CRIS project 1940-32000-061-00D and by a Cooperative Agreement from the United States Department of Agriculture’s Animal and Plant Health Inspection Service (APHIS) . Additional funding was provided by the U.S. Department of State, Biosecurity Engagement Program through the USDA , ARS Office of International Research Programs . Funding Information: Miranda Bertram and Barbara Brito were the recipients of a Plum Island Animal Disease Center Research Participation Program fellowship, administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy (DOE) and the U.S. Department of Agriculture (USDA). All opinions expressed in this paper are the authors’ and do not necessarily reflect the policies and views of the USDA, APHIS, DOE, or ORAU/ORISE. We thank Kuate Wafo Borrel Vicky for his assistance collecting samples in the field. We acknowledge the Institute of Agriculture Research for Development (IRAD), Cameroon, and the School of Sciences and Veterinary Medicine (ESMV) of Ngaoundéré. Publisher Copyright: © 2018

PY - 2018/7/1

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N2 - Foot-and-mouth disease (FMD) is one of the most contagious and economically important livestock diseases worldwide. Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) was recently introduced in 2014. The objective of this study was to characterize vaccine performance in cattle under natural hyperendemic conditions in the Adamawa region of Cameroon. Vaccinated cattle (n = 50) and non-vaccinated controls (n = 100) were monitored by serum and oropharyngeal fluid (OPF) sample collection through a 12-month period. Anti-FMDV non-structural protein (anti-NSP) seroprevalence increased from 59.3% (89/150) at the beginning of the study to 85.8% (103/120) at the end of the study, and FMDV RNA was found in 28% (42/150) of animals overall, despite detection of clinical signs of FMD in only 6 non-vaccinated animals. Viral sequence analysis indicated that subclinical infections of FMDV serotypes O and A were present within the study herds during the study period, which was reflected by an overall increase of anti-NSP seroprevalence during the study. There was no association between vaccination status and seroconversion or prevalence of FMDV RNA in OPF. Younger cattle had higher odds of detection of FMDV RNA in OPF, but older animals were more likely to be seropositive. This study suggests vaccination of herds previously exposed to FMDV may help to limit clinical signs and reduce economic losses caused by FMDV. These findings also suggest that subclinical circulation of FMDV occurs in hyperendemic regions regardless of vaccination.

AB - Foot-and-mouth disease (FMD) is one of the most contagious and economically important livestock diseases worldwide. Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) was recently introduced in 2014. The objective of this study was to characterize vaccine performance in cattle under natural hyperendemic conditions in the Adamawa region of Cameroon. Vaccinated cattle (n = 50) and non-vaccinated controls (n = 100) were monitored by serum and oropharyngeal fluid (OPF) sample collection through a 12-month period. Anti-FMDV non-structural protein (anti-NSP) seroprevalence increased from 59.3% (89/150) at the beginning of the study to 85.8% (103/120) at the end of the study, and FMDV RNA was found in 28% (42/150) of animals overall, despite detection of clinical signs of FMD in only 6 non-vaccinated animals. Viral sequence analysis indicated that subclinical infections of FMDV serotypes O and A were present within the study herds during the study period, which was reflected by an overall increase of anti-NSP seroprevalence during the study. There was no association between vaccination status and seroconversion or prevalence of FMDV RNA in OPF. Younger cattle had higher odds of detection of FMDV RNA in OPF, but older animals were more likely to be seropositive. This study suggests vaccination of herds previously exposed to FMDV may help to limit clinical signs and reduce economic losses caused by FMDV. These findings also suggest that subclinical circulation of FMDV occurs in hyperendemic regions regardless of vaccination.

KW - Cameroon

KW - FMD

KW - Foot-and-mouth disease

KW - Transboundary

KW - Vaccination

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UR - https://www.scopus.com/pages/publications/85045074935#tab=citedBy

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AN - SCOPUS:85045074935

SN - 0167-5877

VL - 155

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JO - Preventive Veterinary Medicine

JF - Preventive Veterinary Medicine

ER -

Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon

Abstract

Bibliographical note

Keywords

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