Effect of topical diphenhydramine on the laryngeal chemoreflex

Holly C Boyer, Daniel H. Downs, George Goding, Kerri J. Pernell

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objective: To study diphenhydramine nebulization as a clinically applicable method for blunting laryngeal chemoreflex (LCR)-associated apnea. Intervention: Fourteen piglets aged 15 to 18 days were studied. In 7 piglets, diphenhydramine hydrochloride (5.0 mg/kg) was nebulized onto the laryngeal mucosa after a baseline response was obtained. Results: After a 10-minute waiting period, the mean±SD LCR-induced apnea duration decreased from 29±13 seconds in the control animals to 15±5 seconds in the treated group (P=.02, 1-factor analysis of variance). After 1 hour, no treatment effect was seen. Conclusions: Nebulization of diphenhydramine can effectively reduce LCR- induced apnea for a short time. Nebulization of longer-acting agents may provide an effective prophylaxis of LCR-induced apnea.

Original languageEnglish (US)
Pages (from-to)1112-1116
Number of pages5
JournalArchives of Otolaryngology - Head and Neck Surgery
Issue number10
StatePublished - Oct 1996


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