Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female rats

Erin B. Larson; Megan E. Roth; Justin J. Anker; Marilyn E. Carroll

doi:10.1016/j.pbb.2005.07.015

Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female rats

Erin B. Larson, Megan E. Roth, Justin J. Anker, Marilyn E. Carroll

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Estrogen effects on cocaine-induced reinstatement of lever responding were examined in sham-operated, vehicle-treated (SH + VEH), ovariectomized (OVX + VEH), and OVX female Wistar rats with estrogen replacement (OVX + EB). The effect of long- (64 ± 1.56 days) and short-term (9 days) EB treatment on reinstatement of cocaine-seeking behavior was compared in Experiment 1 and 2, respectively, in order to compare the effect of EB when it was present during the development vs. expression of reinstatement of cocaine-seeking behavior. Rats were trained to self-administer 0.4 mg/kg/inf cocaine. After the acquisition criteria were met, rats continued to respond for cocaine for 2 h/day for a 14-day maintenance period. Cocaine was then replaced with saline and the 21-day extinction period commenced. Subsequently, rats were tested for reinstatement of lever responding on the previously drug-paired lever after alternating daily injections of saline or cocaine. In both experiments, there were no differences between groups in self-administration behavior during training, maintenance, or extinction. In Experiment 1, SH + VEH and chronically treated OVX + EB rats had greater cocaine-induced reinstatement than OVX + VEH rats. In Experiment 2, short-term treated OVX + EB rats also showed enhanced cocaine-induced reinstatement compared to OVX + VEH rats. The results indicate that EB-mediated enhancement of cocaine-induced reinstatement is dependent on EB presence during the expression of reinstatement but not during the formation of stimulus-reward associations during the development of cocaine-reinforced behavior.

Original language	English (US)
Pages (from-to)	98-108
Number of pages	11
Journal	Pharmacology Biochemistry and Behavior
Volume	82
Issue number	1
DOIs	https://doi.org/10.1016/j.pbb.2005.07.015
State	Published - Sep 2005

Bibliographical note

Funding Information:
The authors would like to thank Paula Whitten, Sarah Nelson, and Jon German for their technical assistance in conducting the experiments, and Jennifer Perry for her critical review of the manuscript. This research was supported by NIDA R01 DA03240, K05 DA 15267 (MEC), and T32 DA07097, F31 DA14161 (MER).

Keywords

Cocaine
Estrogen
Female
Reinstatement
Self-administration

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10.1016/j.pbb.2005.07.015

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title = "Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female rats",

abstract = "Estrogen effects on cocaine-induced reinstatement of lever responding were examined in sham-operated, vehicle-treated (SH + VEH), ovariectomized (OVX + VEH), and OVX female Wistar rats with estrogen replacement (OVX + EB). The effect of long- (64 ± 1.56 days) and short-term (9 days) EB treatment on reinstatement of cocaine-seeking behavior was compared in Experiment 1 and 2, respectively, in order to compare the effect of EB when it was present during the development vs. expression of reinstatement of cocaine-seeking behavior. Rats were trained to self-administer 0.4 mg/kg/inf cocaine. After the acquisition criteria were met, rats continued to respond for cocaine for 2 h/day for a 14-day maintenance period. Cocaine was then replaced with saline and the 21-day extinction period commenced. Subsequently, rats were tested for reinstatement of lever responding on the previously drug-paired lever after alternating daily injections of saline or cocaine. In both experiments, there were no differences between groups in self-administration behavior during training, maintenance, or extinction. In Experiment 1, SH + VEH and chronically treated OVX + EB rats had greater cocaine-induced reinstatement than OVX + VEH rats. In Experiment 2, short-term treated OVX + EB rats also showed enhanced cocaine-induced reinstatement compared to OVX + VEH rats. The results indicate that EB-mediated enhancement of cocaine-induced reinstatement is dependent on EB presence during the expression of reinstatement but not during the formation of stimulus-reward associations during the development of cocaine-reinforced behavior.",

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note = "Funding Information: The authors would like to thank Paula Whitten, Sarah Nelson, and Jon German for their technical assistance in conducting the experiments, and Jennifer Perry for her critical review of the manuscript. This research was supported by NIDA R01 DA03240, K05 DA 15267 (MEC), and T32 DA07097, F31 DA14161 (MER).",

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AU - Larson, Erin B.

AU - Roth, Megan E.

AU - Anker, Justin J.

AU - Carroll, Marilyn E.

N1 - Funding Information: The authors would like to thank Paula Whitten, Sarah Nelson, and Jon German for their technical assistance in conducting the experiments, and Jennifer Perry for her critical review of the manuscript. This research was supported by NIDA R01 DA03240, K05 DA 15267 (MEC), and T32 DA07097, F31 DA14161 (MER).

PY - 2005/9

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N2 - Estrogen effects on cocaine-induced reinstatement of lever responding were examined in sham-operated, vehicle-treated (SH + VEH), ovariectomized (OVX + VEH), and OVX female Wistar rats with estrogen replacement (OVX + EB). The effect of long- (64 ± 1.56 days) and short-term (9 days) EB treatment on reinstatement of cocaine-seeking behavior was compared in Experiment 1 and 2, respectively, in order to compare the effect of EB when it was present during the development vs. expression of reinstatement of cocaine-seeking behavior. Rats were trained to self-administer 0.4 mg/kg/inf cocaine. After the acquisition criteria were met, rats continued to respond for cocaine for 2 h/day for a 14-day maintenance period. Cocaine was then replaced with saline and the 21-day extinction period commenced. Subsequently, rats were tested for reinstatement of lever responding on the previously drug-paired lever after alternating daily injections of saline or cocaine. In both experiments, there were no differences between groups in self-administration behavior during training, maintenance, or extinction. In Experiment 1, SH + VEH and chronically treated OVX + EB rats had greater cocaine-induced reinstatement than OVX + VEH rats. In Experiment 2, short-term treated OVX + EB rats also showed enhanced cocaine-induced reinstatement compared to OVX + VEH rats. The results indicate that EB-mediated enhancement of cocaine-induced reinstatement is dependent on EB presence during the expression of reinstatement but not during the formation of stimulus-reward associations during the development of cocaine-reinforced behavior.

AB - Estrogen effects on cocaine-induced reinstatement of lever responding were examined in sham-operated, vehicle-treated (SH + VEH), ovariectomized (OVX + VEH), and OVX female Wistar rats with estrogen replacement (OVX + EB). The effect of long- (64 ± 1.56 days) and short-term (9 days) EB treatment on reinstatement of cocaine-seeking behavior was compared in Experiment 1 and 2, respectively, in order to compare the effect of EB when it was present during the development vs. expression of reinstatement of cocaine-seeking behavior. Rats were trained to self-administer 0.4 mg/kg/inf cocaine. After the acquisition criteria were met, rats continued to respond for cocaine for 2 h/day for a 14-day maintenance period. Cocaine was then replaced with saline and the 21-day extinction period commenced. Subsequently, rats were tested for reinstatement of lever responding on the previously drug-paired lever after alternating daily injections of saline or cocaine. In both experiments, there were no differences between groups in self-administration behavior during training, maintenance, or extinction. In Experiment 1, SH + VEH and chronically treated OVX + EB rats had greater cocaine-induced reinstatement than OVX + VEH rats. In Experiment 2, short-term treated OVX + EB rats also showed enhanced cocaine-induced reinstatement compared to OVX + VEH rats. The results indicate that EB-mediated enhancement of cocaine-induced reinstatement is dependent on EB presence during the expression of reinstatement but not during the formation of stimulus-reward associations during the development of cocaine-reinforced behavior.

KW - Cocaine

KW - Estrogen

KW - Female

KW - Reinstatement

KW - Self-administration

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DO - 10.1016/j.pbb.2005.07.015

M3 - Article

C2 - 16111740

AN - SCOPUS:26444523082

SN - 0091-3057

VL - 82

SP - 98

EP - 108

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

IS - 1

ER -

Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female rats

Abstract

Bibliographical note

Keywords

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